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Scientist, In Vivo PK

Employer
Sutro Biopharma, Inc
Location
South San Francisco, CA
Salary
$130,000 - $175,000
Start date
Jun 13, 2024

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Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

Position OverviewSutro Biopharma, Inc. is looking for a highly motivated individual with exceptional proficiency in designing and executing in vivo pharmacokinetic models, skills in drug administration by multiple routes, and plasma and tissue sample collection. The Scientist conceives experimental strategies and leads the design and conduct of experiments in biological systems to characterize the pharmacokinetics and tissue distribution of potential therapeutics to prioritize them for further development. This individual possesses knowledge of relevant experimental biology techniques, including pharmacokinetic and metabolism methodologies; participates in technology development in the area of in vitro assays, cell biology, or in vivo testing; interprets, and communicates experimental findings and documents according to approved policy; maintains broad knowledge of state-of-the-art principles and theories, and develops and analyzes new product concepts by reviewing preclinical and clinical literature; mentors and guides junior scientists and may manage research associates.  This position contributes to and supports the company’s research and development efforts to create high-value therapeutics to address unmet medical needs. Responsibilities
  • Conduct in vivo pilot toxicology and pharmacokinetic studies of small molecules and biologics in rodent models.  
  • Grow tumor cells, implant cells into animals and perform PK-PD studies. 
  • Performs necropsy and tissue harvesting.  
  • Comply with IACUC and AAALAC regulations by renewing, amending, and developing protocols. 
  • Understand and implement study protocols according to IACUC guidelines. 
  • Expertise in handling and dosing rodents and administering test articles via various routes. 
  • Prepares basic formulations and dosing solutions.   
  • Maintain study records/files, provide written materials and methods sections for technical reports. 
  • Manage samples (including receipt from external parties and in-house) 
  • Maintain familiarity with current relevant in vivo PK-PD models to support preclinical development and investigational new drug application filings. 
  • Able to work and solve problems independently (i.e., without direct supervision) on routine work. 
  • May supervise, mentor, and train junior personnel. 
  • Act as a principal investigator in conducting in-house and CRO studies, including but not limited to generating SOW’s, protocol generation/review, and monitoring study progression. 
  • Work collaboratively with teams across multiple functions. 
  • Plan and budget for animal procurement.  
  • Required to work occasionally on weekends and Holidays. 
Qualifications: 
  • A BA or BS in biological science is required; an MS or PhD in a scientific discipline is a plus.
  • A minimum of 8+ years of in vivo PK studies in small animals. Experience with large animals is not required but is a plus.
  • Understands rodent physiology and anatomy.
  • Former membership of IACUC is a must. 
  • Demonstrates superior organizational skills. 
  • Being resourceful is a requirement.
  • Familiar with PK-PD animal models.
  • Familiarity with Health Hazard Classes is required.
  • Working experience with ADC, PEGylated molecules, and small molecules is preferred.
  • Familiar with relevant FDA and ICH guidances.
  Sound exciting? Apply today and join our team!Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.  As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.  We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.   The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California-based locations will be $130,000 - $175,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education. 

About Sutro Biopharma     

Sutro Biopharma, Inc., is a clinical-stage company relentlessly focused on the discovery and development of precisely designed cancer therapeutics, transforming what science can do for patients. Sutro’s fit-for-purpose technology, including cell-free XpressCF®, provides the opportunity for broader patient benefit and an improved patient experience. Sutro has multiple clinical stage candidates, including luveltamab tazevibulin, or luvelta, a registrational-stage folate receptor alpha (FRα)-targeting ADC in clinical studies. A robust pipeline, coupled with high-value collaborations and industry partnerships, validates our continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.  

Company

sutro

 

Sutro Biopharma, Inc., is a clinical-stage company relentlessly focused on the discovery and development of precisely designed cancer therapeutics, transforming what science can do for patients. Sutro’s fit-for-purpose technology, including cell-free XpressCF®, provides the opportunity for broader patient benefit and an improved patient experience. Sutro has multiple clinical stage candidates, including luveltamab tazevibulin, or luvelta, a registrational-stage folate receptor alpha (FolRα)-targeting ADC in clinical studies. A robust pipeline, coupled with high-value collaborations and industry partnerships, validates our continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.

Stock Symbol: STRO

Twitter

 

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Bill Newell, CEO Interviewed by Brad Loncar, Founder, Biotech TV – “Sutro Biopharma’s CEO on ADCs, non-cell protein synthesis, and more" - view it here 

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Company info
Website
Phone
650.881.6500
Location
111 Oyster Point Blvd
South San Francisco
California
94080
US

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