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Associate Director, Hit Discovery

Life Edit Therapeutics
Durham, NC
Start date
Jun 2, 2024

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Science/R&D, Biotechnology, Molecular Biology
Required Education
Position Type
Full time
Bio NC

Job Details

The Role:

Life Edit is seeking an experienced scientific leader with direct industry experience in therapeutic hit discovery.  The selected candidate will report to the Director, Gene Editing and lead a group of scientists to perform target exploration within the Gene Editing team. 


Here’s What You’ll Do:

  • Lead a diverse scientific team to devise gene editing strategies for targets of interest, execute editing screening campaigns, and perform hit-to-lead activities including in vitro proof-of-concept and mechanism of action studies
  • Work closely with Corporate Development to help identify novel therapeutic targets, taking into account multiple factors including technical feasibility, commercial opportunity, and business strategy
  • Collaborate with the Computational Biology, Technology Development, and Preclinical teams to deploy Life Edit’s array of genome editing systems and move lead editing compositions into animal models
  • Ensure hit discovery and optimization activities meet key milestones in a timely manner
  • Critically summarize and present data internally to interdisciplinary teams and leadership, as well as externally
  • Write reports summarizing hit discovery and optimization activities suitable for inclusion in regulatory documents



  • Ph.D. in biology, biochemistry, molecular biology, or a related field with 10+ years of relevant experience
  • Direct experience with hit discovery and hit-to-lead activities in the pharmaceutical or biotechnology sectors, industry experience preferred
  • Experience leading a scientific team, preferably in an industry setting
  • Demonstrated ability to collaborate in a cross functional, team-oriented environment
  • Exceptional oral and written communication skills
  • Relevant technical skills for data analysis, electronic lab notebook documentation, and presentations
  • Direct experience in the gene editing field is strongly preferred
  • A broad background in a variety of areas in biology and human therapeutics is advantageous


We’re committed to finding the best ways to support our teams so they can do their best work. We take care of our employees, right from the start.


Health & Wellness

  • Medical, vision, and dental insurance covered at 90%
  • Low deductible, no co-insurance and no copays for mental health visits (for in-network care)
  • Annual fitness reimbursement
  • Employer paid for access to wellness apps and programs like Task Human



  • Competitive compensation
  • 401(k) retirement plans with a 4% employer match and no vesting period
  • Employer-paid life insurance and short- and long-term disability insurance
  • Employer-sponsored flexible spending accounts (FSA) and dependent care account (DCA)
  • Access to a 1-on-1 financial advisor
  • Commuter reimbursement benefit
  • Monthly cell phone stipend


Time Off & Flexibility

  • Unlimited paid time off, including vacation, sick leave, family leave, personal days, and bereavement
  • 18 paid company holidays, plus an end-of-year holiday shut down
  • 12 weeks of parental leave
  • Federal Family and Medical Leave Act (FMLA) and Massachusetts Paid Family and Medical Leave (PFML), administered by Unum


Development Journey

  • Insights Discovery training for every employee to make the most of workplace relationships
  • Ongoing professional development, including manager training
  • Access to LinkedIn Leaning, a self-guided online education platform

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.


Life Edit Therapeutics is an ElevateBio company focused on advancing next-generation gene editing technologies and therapeutics. Life Edit has built a highly innovative platform with one of the world’s largest and most diverse libraries of RNA-guided nucleases (RGNs), base editors, and reverse transcriptase (RT) editors that provide flexible editing and unprecedented access to the genome. The platform allows Life Edit to target any genomic sequence and potentially develop novel human therapeutics for the most challenging genetic diseases by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies.

Company info
300 Morris Street, Suite 300

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