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Principal Engineer - Medical Device Design (Boston, MA)

Eli Lilly and Company
Cambridge, Massachusetts
Start date
May 30, 2024

Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The DDCS Innovation function plays a vital role in Lilly’s mission to bring pioneering technology for the delivery of healthcare by investigating novel technologies both internally and through external collaborations that can assist in fulfilling this mission. The Innovation team will consist of core technology-focused science and engineering fields along with key external innovation subject matter authorities. Together this group will own new investments in delivery and device technologies that span all therapeutic areas.

We are seeking an Sr. Principal/Principal Engineer in DDCS Drug Delivery and New Product Innovation to design novel drug delivery procedures, methodologies, and devices. This individual will be responsible for mechanical and electro-mechanical engineering across multiple drug delivery platforms starting from the earliest stages of research and development.  Responsibilities will include a combination of new product ideation, concept development, mechanical design (in Solidworks), prototyping, fabricating, laboratory work, and literature research. You will be working at the cutting edge of drug delivery, helping enable new-to-the-world therapies being developed across Lilly Research Labs. Projects may include the support and expansion of existing therapies as well as designing delivery solutions for first-in-human use.

Key Objectives/Deliverables:

  • Play a key technical role in the design and development of innovative drug delivery solutions to enable current and future drug portfolio assets.
  • Participate in ideation activities for new products, delivery methodologies, and new procedures – may include both benchtop and ex vivo tissue experimentation.
  • Design and create device prototypes for use in laboratory testing, ex vivo testing, and in vivo testing.
  • Design and fabrication of test setups – including test fixtures to support prototype testing and characterization of current devices via sensors and instrumentation.
  • Collect, analyze, and present data from experiments to project team, including recommendations for next steps.
  • Work with external vendors including CMO’s and CRO’s to create prototypes, early in vivo testing setups, and perform in vivo experimentation.


  • Network and collaborate across functional groups and departments within a large, multidisciplinary company.
  • Mentor more junior engineers and interns/coops.
  • Assist in perpetuating an environment of collaboration and innovation, along with an expectation for step change improvement.

Basic Qualifications:

  • BS in engineering, preferably in mechanical or electro-mechanical engineering (MS preferred), with 5+ years of experience in medical device or combination product design and development
  • Experience and comfort with the ambiguity of early-stage R&D and innovation.
  • Experience in designing combination products and procedures, including parenteral, inhalation, transdermal, intrathecal, and other direct CNS drug delivery methodologies.

Additional Skills and Preferences:

  • Expert use of CAD (SolidWorks), working knowledge scripting (Python, Matlab) for data acquisition, instrument control and data analysis. Knowledge of statistical analysis (JMP, R) and Good Documentation Practices in a regulated environment.
  • Strong laboratory experimentation skills, including rapid prototyping, fluid handling, fabrication, sensors and instrumentation, and design of experiments.
  • Knowledge of anatomy and physiology, particularly of the central nervous system is highly desirable.
  • Works well in small, multidisciplinary teams and as an individual contributor.
  • Strong mechanical and product design skills, preferably in drug delivery and/or surgical products
  • Intellectual curiosity and a desire to constantly learn and grow to help solve complex problems.
  • Experience with drug pumps, their design and testing.
  • Experience and understanding of the medical device lifecycle, design control, and general quality and regulatory requirements of stand-alone and combination devices.
  • Working knowledge of the drug development process, including the chemistry and manufacturing side of drug delivery systems preferred.
  • Enjoys the challenge of unsolved problems and understands the possibility of multiple solutions.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.



Science has been our calling from the beginning. Colonel Eli Lilly founded the company in 1876 and charged employees to “take what you find here and make it better and better.” More than 147 years later, we remain committed to his vision through every aspect of our business and the people we serve, starting with discovering the best treatments for those who take our medicines and extending to health care professionals, employees and the communities in which we live. Moreover, you can also count on the team at Lilly to be incredibly civic-minded, supporting our communities through philanthropy, volunteerism, and a creative and innovative can-do spirit. 

Company info
893 S Delaware St
United States

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