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Principal Research Associate, Process Development

Neogene Therapeutics
Santa Monica, CA
Start date
May 29, 2024

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Job Details

At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Position Summary

The Principal Research Associate, Process Development is responsible for supporting and contributing to the design and execution of studies to develop and further optimize clinical manufacturing processes of Neogene portfolio of engineered TCR T cell therapies. This role is based in Santa Monica, CA, and reports to the Senior Scientist, Process Development.



  • Participate in the design, execution and support of laboratory studies for development, optimization, and manufacture of genome engineered TCR T cell products using non-viral genome editing tools.
  • Execute and support analytical methods for process development studies.
  • Support experimental designs, planning, execution, analysis, and reporting results of process development studies.
  • Participate in a cross-functional team to transfer technology to cGMP manufacturing partners.
  • Support, author, and review protocols, technical reports, regulatory documents and memos to summarize experiments and investigations.
  • Collaborate with internal and external partners to evaluate and implement new process technologies to develop next generation processes.
  • Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.
  • Work effectively in a team environment to meet project timeline and objectives.
  • Perform other duties as assigned.


Supervisory Responsibilities

  • Oversee Junior associates in execution of development activities.


Education and Experience

  • 8+ years with High School; 4+ years with BS/BA; 2+ years with MS/MA in Immunology, Cell Biology, Molecular biology, Bioengineering; 2+ years with Eng Degree 
  • At least 3 years of relevant experience in developing production processes for genome engineered primary cells (required) including T cells (highly preferred).
  • A minimum of two (2) years practical experience with Flow Cytometry.
  • Hands-on experience performing analytical methods typically used in the manufacture and characterization of biological products.
  • Proficiency with Microsoft Excel or statistical analysis software (JMP, Minitab, Prism, etc.) for analyzing and presenting data.
  • Working understanding of US/EU regulatory requirements and working knowledge of cGMPs.
  • Ability to think critically, analytically and have demonstrated troubleshooting and problem-solving skills based on deductive reasoning.
  • Ability to design and execute experiments with minimal technical supervision.


The anticipated salary range for candidates who will work in Santa Monica, CA is $85,000 to $100,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job type and length of experience within the industry, education, etc.



  • Short-term incentive bonus opportunity
  • Equity-based long-term incentive program
  • 401(k) plan
  • Paid vacation and holidays; paid leaves
  • Health benefits including medical, prescription drug, dental, and vision coverage.

DE&I Statement

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.


Neogene Therapeutics is a global, preclinical stage biotechnology company pioneering the development of next generation, fully individualized engineered T cell therapies for a broad spectrum of cancers.

Our proprietary neoantigen T cell receptor (TCR) discovery and T cell engineering platform identifies TCR genes with specificity for neoantigens – found exclusively on cancer cells as a result of cancer-associated DNA mutations.

Cancer is a genetically individual disease – no two tumors are exactly the same. These variations create neoantigens – unique targets for every tumor. Neogene’s novel approach delivers a tailored T cell therapy containing a unique set of specific TCR genes for each individual patient. Engineered into patient-derived T cells, these TCRs are directed toward neoantigens in tumor cells, with the goal of eliciting strong and durable responses in a variety of solid tumor indications.

We offer the opportunity to join a highly dynamic biotech start-up. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career.

Company info
2225 Colorado Avenue
Santa Monica
United States

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