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Senior Research Associate, Translational Sciences

Neogene Therapeutics
Santa Monica, CA
Start date
May 26, 2024

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Job Details

At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Position Summary

The Senior Research Associate is responsible for supporting Neogene's efforts in developing TCR-based immunotherapies for solid tumors. You will be expected to perform experiments, organize and analyze results, and communicate and present findings in team meetings as well as provide support during regulatory filings. You will also be asked to perform other duties as required. This role will be a hands-on based in Santa Monica, CA and reporting into a Principal Scientist.


  • Execute cell-based functional assays to select and characterize candidate molecules for clinical development.
  • Execute in vitro assays and mouse models to address basic efficacy and safety aspects of the selected candidate molecules.
  • Maintain, bank and engineer cell lines using viral and non-viral techniques to support in vitro and in vivo assays.
  • Analyze biospecimens from clinical trial.
  • Document laboratory procedures and experiments with great attention to detail.
  • Analyze, organize, and communicate results at team meetings.
  • Provide support in writing and reviewing reports and/or data verification during regulatory filings.
  • Other duties as assigned.

Education and Experience

  • 3+ years with BS or 0+ years with MS in related scientific discipline
  • Background in immunology and/or immunotherapy is strongly preferred. Prior experience in working with engineered T-cells is desired.
  • Proficient in cell culture aseptic techniques.
  • Hands-on expertise in maintaining multiple human cell lines.
  • Hands-on experience with T-cell functional characterization assays including in vitro cytotoxicity, proliferation, and cytokine/chemokine measurements.
  • Ability to prepare, acquire, and analyze samples for multi-parameter flow cytometric studies
  • Strong organizational and record keeping skills.
  • Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment.
  • Self-motivated and comfortable in a fast-paced company environment with minimal direction.
  • Willing to accept temporary responsibilities outside of initial job description.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base salary for this position ranges from $70,000 to $82,000. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related experience. If hired, employee will be in an “at-will position” and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.


  • Short-term incentive bonus opportunity
  • Equity-based long-term incentive program
  • 401(k) plan
  • Paid vacation and holidays; paid leaves
  • Health benefits including medical, prescription drug, dental, and vision coverage.

Neogene Therapeutics requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

DE&I Statement

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.


Neogene Therapeutics is a global, preclinical stage biotechnology company pioneering the development of next generation, fully individualized engineered T cell therapies for a broad spectrum of cancers.

Our proprietary neoantigen T cell receptor (TCR) discovery and T cell engineering platform identifies TCR genes with specificity for neoantigens – found exclusively on cancer cells as a result of cancer-associated DNA mutations.

Cancer is a genetically individual disease – no two tumors are exactly the same. These variations create neoantigens – unique targets for every tumor. Neogene’s novel approach delivers a tailored T cell therapy containing a unique set of specific TCR genes for each individual patient. Engineered into patient-derived T cells, these TCRs are directed toward neoantigens in tumor cells, with the goal of eliciting strong and durable responses in a variety of solid tumor indications.

We offer the opportunity to join a highly dynamic biotech start-up. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career.

Company info
2225 Colorado Avenue
Santa Monica
United States

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