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Discovery Lead, Liver (Senior Director)

Boston, Massachusetts
Start date
May 24, 2024

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Clinical, Clinical Development, Science/R&D
Required Education
Bachelors Degree
Position Type
Full time
Genetown, Best Places to Work

Job Details

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.


Join Takeda as a Director, Liver Disease Research where you will lead research programs in collaboration with internal and external partners focused on the development of novel anti-fibrotic drug candidates for the treatment of chronic liver diseases. You will be a strong scientific thinker with significant experience leading the discovery and development of oligonucleotide therapies for liver diseases and have extensive experience developing and/or evaluating novel nucleic acid-based therapeutics and delivery platforms As part of the Gastroenterology Drug Discovery Unit (GI DDU), you will report to the Head of Liver Research and support, evaluate and/or identify business development opportunities to enhance project progression and/or platform expansion, with specific application to the needs of the liver portfolio including nucleic acid-based therapeutics and delivery platforms.


  • Develop and oversee novel scientific projects and manage the work of others directly and in a matrixed structure.
  • Lead efforts to determine mechanisms of action for drug targets and candidates using state-of-the-art methods and tools.
  • Oversee the execution of drug candidate and platform development programs, using contemporary methods and tools in collaboration with internal and external partners.
  • Proactively identify complex obstacles to progress; recommend and implement solutions using a diverse set of resources; contribute to research projects through creative ideas.
  • Determine methods for new assignments; make strategic recommendations on projects.
  • Seek in-licensing opportunities that bring innovative approaches to the treatment of liver diseases.
  • Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce a quality result with a high level of efficiency.
  • Be a scientific mentor.
  • Communicate effectively with colleagues and leadership.


  • Ph.D. degree in a scientific discipline with 15+ years of experience in the discovery and development of oligonucleotide therapies for liver diseases, or
  • MS with 21+ years of experience, or
  • BS with 23+ years of experience.
  • 9 years of Industry experience required.
  • 9 years of managerial experience required.
  • Significant understanding of complex biological systems.
  • Proven ability to effectively interact with technical, scientific staff, and research management.
  • Expertise in ASOs/siRNA and/or base editing therapeutics and delivery technologies.
  • Expertise in the design and execution of in vivo and in vitro studies for the evaluation of liver-related biology and pathology.
  • Solid understanding of in silico and computational approaches in drug development.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$205,100.00 - $322,300.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

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Stock Symbol: TAK

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650 East Kendall Street

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