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Senior Scientist, Analytical Development

Employer
Neogene Therapeutics
Location
Santa Monica, CA
Start date
May 22, 2024

Job Details

At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Position Summary

We are seeking a highly motivated Senior Scientist to join our Analytical Development (AD) team. The successful candidate should have strong expertise in immuno-oncology and will be focused on focus on the development of fit-for-purpose CMC assays using flow cytometry and cell-based immunoassays, to characterize engineered TCR-T cell drug substance and drug product. This role is based out of Santa Monica, CA and reports directly to the Director, Analytical Development.

Essential Functions and Responsibilities

  • Design and develop robust analytical assays for characterizing T-cell therapy drug substance and drug products using flow cytometers and/or other immunoassays.
  • Author assay development and qualification reports with solid datasets to evaluate assay characteristics.
  • Perform analytical assays to provide insights for process and product.
  • Drive assay life cycle, including assay optimization, transfer, and qualification.
  • Work with Tech Operations cross-functional teams to draft study protocols, change controls and technical reports.
  • Author and review relevant CMC sections for regulatory submissions.
  • Lead projects and represent bioassay function and effectively communicate progress or issues in CMC sub-team meetings.
  • Perform routine assays as a QC personnel for drug product release and characterization.

Required Skills/Abilities

  • PhD in Immunology, Oncology, Cell Biology, or related discipline with 2+ years of relevant academic or industry experience
  • In-depth knowledge in immunology and cell therapy with hands-on experience working with T cells is preferred.
  • Extensive hands-on experience in executing assays and analyzing data using multi-color flow cytometry (+10 colors).
  • First-hand experience in different cell-based assays (e.g., Live imaging, ELISA, or MSD) is preferred.
  • Prior working experience in a regulated environment (GLP, GMP or QC) is a plus.
  • Technical-driven, detail-oriented data analysis skills and record keeping abilities.
  • Excellent verbal, written and presentation skills for scientific studies and projects.
  • Enjoy a fast-paced, dynamic company environment and able to adjust workload based upon changing priorities.

 

The anticipated salary range for candidates who will work in Santa Monica, CA is $125,000 to $149,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job type and length of experience within the industry, education, etc.

 

 

DE&I Statement

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Company

Neogene Therapeutics is a global, preclinical stage biotechnology company pioneering the development of next generation, fully individualized engineered T cell therapies for a broad spectrum of cancers.

Our proprietary neoantigen T cell receptor (TCR) discovery and T cell engineering platform identifies TCR genes with specificity for neoantigens – found exclusively on cancer cells as a result of cancer-associated DNA mutations.

Cancer is a genetically individual disease – no two tumors are exactly the same. These variations create neoantigens – unique targets for every tumor. Neogene’s novel approach delivers a tailored T cell therapy containing a unique set of specific TCR genes for each individual patient. Engineered into patient-derived T cells, these TCRs are directed toward neoantigens in tumor cells, with the goal of eliciting strong and durable responses in a variety of solid tumor indications.

We offer the opportunity to join a highly dynamic biotech start-up. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career.

Company info
Website
Location
2225 Colorado Avenue
Santa Monica
CA
90404
United States

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