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Principal Research Scientist II/Senior Principal Research Scientist - Antibody Drug Conjugate

North Chicago, IL
Start date
May 19, 2024

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Job Details

Company Description

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 50,000 people worldwide and markets medicines in more than 170 countries.

AbbVie Process Chemistry is responsible for the chemical development of AbbVies clinical candidates. We are seeking a Principal Research Scientist II to conduct process research and development of antibody-drug conjugates from pre-clinical through clinical development.

Job Description

We are looking for a highly motivated person who can drive the development of antibody-drug conjugate drug substances, from FIH programs to late-stage development. The candidate will lead a group of scientists in the development of conjugation chemistry as well as downstream unit operations culminating in drug substance and may have supervisory responsibilities. The candidate will serve as the chemistry representative on the CMC team for ADC development programs and as such would be responsible for developing timelines and executing activities required for drug substance. The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions. Working with analytical and manufacturing colleagues, the candidate will develop productive collaborations and communications with scientific teams.


  • The candidate will lead activities associated with process development and characterization for new ADC drug substances.
  • Lead the design and execution of process development and control strategies.
  • Lead process chemistry development for FIH programs.
  • Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
  • Author and review key regulatory documents, laboratory data, technical memos and reports.
  • Collaborate to ensure successful CMC interactions with regulatory authorities.
  • The position involves multi-disciplinary interactions with other chemists, analytical chemists, engineers, drug product development, and program management. The selected candidate will collaborate with Asset Development Teams to advance clinical candidates. It is expected that the candidate will utilize his/her expertise across CMC disciplines to further program goals via collaborations with drug product development, regulatory affairs, and commercial operations.
  • The candidate will encourage ideas for continuous improvement activities and initiatives within work group.
  • The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.

  • BS (16+ years); MS (14+ years) or PhD (8+ years) in Chemistry or allied field, with 8+ years of previous work experience in a pharmaceutical laboratory setting.
  • Experience in antibody-drug conjugate process development.
  • The successful candidate will have a strong understanding of process development, control strategy development, regulatory starting material strategies, specification setting, QbD principles, tech transfer and process validation requirements.

Key AbbVie Competencies:

  • Interacts well with diverse groups within function and maintain strong working relationships with internal and external collaborators to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Level and compensation will be commensurate with experience.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

  • The compensation range described below is the range of possible base pay compensation that the Company believesingood faith it will pay for this role at the time of this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, and we mayultimatelypay more or less than the posted range. This range may be modified in the future.

  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligible employees.

  • This job is eligible to participate in our short-term incentive programs.

  • This job is eligible to participate in our long-term incentive programs.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensationand benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

Stock Symbol: ABBV

Stock Exchange: NYSE

Company info
1 North Waukegan Road
North Chicago

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