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Principal Scientist - Antibody Discovery / Engineering

Eli Lilly and Company
San Diego, California
Start date
May 19, 2024

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Biotech Beach, Best Places to Work

Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record for delivering novel biotherapeutic medicines to advance into clinical research in key areas of unmet medical need including diabetes, oncology, immunology, neuroscience, and others.

Antibody display/engineering associate to join our Display Group responsible for the discovery of novel therapeutic antibodies. The successful candidate should possess solid general molecular biology, microbiology and laboratory skills and apply theoretical, technical and - if possible - hands-on expertise in display/discovery and engineering technologies to help evaluate, optimize and identify lead antibody molecules for clinical development.


  • Support discovery and engineering efforts using emerging technologies for antibody display including affinity maturation

  • Execute antibody discovery and engineering strategies for lead identification and optimization

  • Run in-house processes for library construction for discovery, and perform library screening and selections

  • Independently perform complex experiments with attention to quality, detail and documentation

  • Interpret data, troubleshoot experiments and present work at internal meetings

Basic Qualification

  • Bachelor's degree in Biology or related field.

  • 5+ years of experience in Antibody discovery and/or Engineering

Preferred Requirements/Skills

  • Knowledge and hands-on experience in library construction and/or screening

  • Experience with yeast, phage, RNA display and/or other discovery and molecular evolution technologies

  • Experience in FACS technology, applied to screening and selection activities

  • Prior work with antibody libraries, affinity maturation and antibody/protein engineering would be a plus

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.



Science has been our calling from the beginning. Colonel Eli Lilly founded the company in 1876 and charged employees to “take what you find here and make it better and better.” More than 147 years later, we remain committed to his vision through every aspect of our business and the people we serve, starting with discovering the best treatments for those who take our medicines and extending to health care professionals, employees and the communities in which we live. Moreover, you can also count on the team at Lilly to be incredibly civic-minded, supporting our communities through philanthropy, volunteerism, and a creative and innovative can-do spirit. 

Company info
893 S Delaware St
United States

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