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Scientist I / Senior Scientist – Immunology

Employer
Nurix Therapeutics
Location
San Francisco, CA
Start date
May 16, 2024

View more

Discipline
Science/R&D, Biotechnology, Immunology
Required Education
Masters Degree/MBA
Position Type
Full time
Hotbed
Biotech Bay

Job Details


Position

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of immunology and oncology. This individual will work closely with our drug discovery project teams on optimization and characterization of novel compounds to evaluate their impact on immune cells and disease-relevant biology. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a dynamic company.


Qualifications

  • Ph.D. in immunology, biomedical sciences, cancer biology, or related field with 0-2 years industry experience (Scientist I), 3-4 years of industry experience (Scientist II), or 5-6 years of industry experience (Senior Scientist). M.S. with additional industry experience will also be considered.
  • Research experience in the field of immunology, experience with B cells and myeloid cells is a plus.
  • Expertise in functional assays measuring cellular activation, differentiation, cytokine release, proliferation, and migration.
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary cell isolation, ELISA, western and multiplexing technologies.
  • Background in cellular signaling or ubiquitin biology is a plus.
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments.
  • Senior Scientist: experience leading preclinical drug discovery project teams and/or writing IND reports is a plus.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative; solutions and results-oriented focus

Strong scientific curiosity and initiative; hands-on and resourceful

Self-driven and enthusiastic with the ability to thrive in a dynamic environment


Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. 

Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California


Application Process

Please apply by sending your CV to http://www.nurix-inc.com/careers/.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info
Website
Phone
415-660-5320
Location
1700 Owens Street
Suite 205
San Francisco
California
94158
US

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