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Associate Scientist II - Analytical Development

Employer
Novo Nordisk
Location
Boulder, CO
Start date
May 10, 2024

Job Details

About the Department   

The Boulder Site is home to the specialized technical operations/CMC team for oligonucleotides and RNAi therapeutics, continuing its legacy as the hub for all manufacturing-related activities for GalXC™ and GalXC-Plus™ investigational therapeutics developed from Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021. With a new laboratory completed in 2021 to support analytical and process development, the CMC team works alongside Quality, Regulatory, Technical Operations and RNAi Early Development professionals at our Boulder, Colorado facility and works closely with our teams in Lexington, Massachusetts. Ranked the No. 1 Place to Live for the second consecutive year by U.S. News & World Report, Boulder is experiencing a renaissance in biotech investment and is one of the world’s leading centers for oligonucleotide innovation and manufacturing. Together, we are driving change. Are you ready to make a difference?

The Position

Novo Nordisk is seeking a highly motivated associate scientist to join the Analytical Development team in Boulder, CO. The candidate will be responsible for method development in the laboratory for support in analyses of phosphoramidites, oligonucleotides, intermediates and drug products. Experience in analytical method development, transfer, and validation in a cGMP environment with hands on experience using UHPLC's, LC-MS for amidites, oligonucleotides and intermediates is desired. This position will support therapeutic programs in multiple disease areas and be a key contributor in supporting the technical operations team for Dicerna and Novo Nordisks' GalXC and GalXC+ platform products.

 

Relationships

This position reports to the Manager, Analytical Development as an individual contributor. Daily interaction with other peers in analytical development and/or process development teams in support of early phase product pipeline.

 

Essential Functions

  • Primary responsibility to provide analytical lab support for Novo Nordisks’ Oligonucleotide early phase pipeline
  • Development of robust IPRP, AX or mixed mode HPLC analytical methods for testing highly modified oligonucleotide drug substances, in-process samples, custom starting materials and drug products
  • Prepare analytical samples, analyze and process data, primarily by HPLC, LC-MS, KF, GC-FID/MS, etc.
  • Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides
  • Conduct Phase appropriate method qualifications as necessary
  • Operate, and troubleshoot lab instruments
  • Keep accurate records of the experiments utilizing GDP documentation and summarize the results in well communicated presentations or written reports
  • Contribute data for characterization and analytical sections of regulatory submissions
  • Possess excellent written and verbal communication skills
  • Conduct laboratory work in an efficient manner that ensures a safe working environment
  •  

    Physical Requirements

    0-10% overnight travel required.

     

    Qualifications

  • MS with 3+ years of industrial experience, or BS with 5+ years of industrial experience
  • Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics
  • Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Agilent, Waters and/or Thermo UHPLC’s and associated software
  • In depth knowledge of GLP/GMP’s in a pharmaceutical environment
  • The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
  • The base compensation range for this position is $80,000 to $120,000. Base compensation is determined based on a number of factors. This position is also eligible for a company bonus based on individual and company performance.  
     
    Novo Nordisk offers long-term incentive compensation and or company vehicles depending on the position's level or other company factors.  
     
    Employees are also eligible to participate in Company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flex-able vacation policy, and parental leave policy. 

     

    The job posting is anticipated to close on 06/09/2024. The Company may however extend this time-period, in which case the posting will remain available on our careers website at www.novonordisk-us/careers.com.

     

    We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

     

    At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

     

    Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

     

    If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.

    Company

    Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 54,400 people in 80 countries and markets its products in around 170 countries. For more information visit novonordisk.com.

    Our US Research & Development hub, located in the Greater Boston area, brings together the best talent to drive life science innovation. Located in Lexington, Watertown and Cambridge, our teams reflect the full scope of R&D, from early research through late-stage clinical development. We are building for the future by creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. By combining the speed and agility of biotech with the quality, resources, and stability of a large pharmaceutical company, our US R&D hub will benefit from the best of both worlds to develop new medicines that meet the needs of patients.

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    Company info
    Website
    Phone
    617-612-6200
    Location
    75 Hayden Avenue
    Lexington
    MA
    02421
    US

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