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Associate Scientist I, Analytical Development for Characterization

Employer
Vaxcyte, Inc.
Location
San Carlos, California
Start date
Apr 19, 2024

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Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
 
Summary:
 
We are seeking a highly motivated and detail-oriented Associate Scientist to join our Analytical development team in conducting experiments for Liquid Chromatography-Mass Spectrometry (LCMS) analysis. The successful candidate will play a crucial role in supporting our development efforts by performing LCMS experiments, analyzing data, and contributing to the interpretation of result. The candidate will work in a fast-paced environment, must be a collaborative team player, has a strong desire to learn new techniques and concepts, and be committed to Vaxcyte mission.
Essential Functions:
    • Prepare samples for analysis, execute analytical procedures according to the SOP, and perform data analysis.
    • Provide assay supports to PD.
    • Assist in developing and implementing mass spectrometry-based workflows for characterization of proteins, conjugates, and other in-process molecules.
    • Operate, maintain, and troubleshoot mass spectrometry instruments.
    • Analyze data using appropriate software tools. Interpret, communicate, and present data.
    • Assist with authoring and maintaining standard operating procedures.
    • Document results of analyses and experiments with an electronic notebook system.
    • Support cross-functional teams with their analytic needs based on mass spectrometry.

Requirements:
    • BA in Chemistry, Biochemistry and Biology or a related discipline, with 2-4 years of relevant experience, or MS with 1-2 years of experience.
    • Prior hands-on experience in a laboratory setting.
    • Basic understanding of mass spectrometry technologies.
    • Hands-on experience with peptide mapping and intact analysis by LCMS is highly desirable.
    • Highly organized, strong attention to details and excellent record keeping/documentation abilities.
    • Critical thinking and ability to analyze data.
    • Eager and able to learn and understand new concepts with ease.
    • Strong interpersonal skills and ability to communicate effectively with team members.
    • Ability to work under supervision and collaborate effectively with team members.
    • Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work.
    • Familiarity with mass spectrometry techniques such as tandem mass spectrometry (MS/MS) and high-resolution mass spectrometry (HRMS)
    • Experience with method development and validation for LCMS analysis.
    • Experience with HPLC chromatography for proteins and conjugate.
    • Experience with Chromatography-based quantification strongly preferred.

Reports to: Senior Scientist, Analytical Development
 
Location: San Carlos, CA
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $74,000 – $88,000
 
 

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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