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Sr. Scientist, Analytical Development (Protein)

Employer
Vaxcyte, Inc.
Location
San Carlos, California
Start date
Apr 16, 2024

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Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
 
Summary:
 
Looking for an energetic and talented individual to join our Analytical Development team. Primary responsibility for the incumbent will be to support the developmental activities currently on going in the laboratory as assigned.
Essential Functions:
    • Provide strategic, tactical and technical leadership in the development of analytical methods for the purpose of characterizing drug product, drug substance, intermediates and critical raw material.
    • Take on end-to-end responsibility of method development for characterization of proteins, bacterial polysaccharides, polysaccharide-protein conjugates, and adjuvanted vaccines product. Responsibility also includes resource planning, team productivity and timeline management of the deliverables.
    • Drive analytical innovation and stay on top of cutting-edge analytical technology. Introduce and establish novel technology in house if necessary.
    • Provide technical direction, mentorship and coaching to the analytical characterization team.
    • Manage performance and development of personnel (2-4) to ensure achievement of organizational and department goals.
    • Collaborate with Formulations and Process Development to provide analytical solutions for process understanding, troubleshooting and characterization.
    • Author technical reports and analytical method.
    • Cultivate a cohesive, innovative, nimble and productive team environment.

Requirements:
    • PhD in Chemistry, Analytical Chemistry, Biochemistry, or related field with 5+ years relevant industry experience; MS or BS with 8+ years of industry experience in Pharma /Biotech industry required.
    • Proven leadership skills.
    • Outstanding organization and planning skills.
    • Must be a strong scientific leader who can guide scientists with clear goals of developing analytical methods, and critically and skillfully review and assess analytical methods under development. May need to provide direction for troubleshooting various issues during method development.
    • Proven track record of analytical development leadership for biologics and small molecules, experience with vaccines, carbohydrate, or conjugates is a plus.
    • Extensive expertise in U/HPLC, CE, SDS-PAGE, mass spectrometry, and other analytical technologies as applied to protein analytical method development, trouble shooting and validation for GMP release and stability testing.
    • Experience in protein characterization by using different analytical approaches, such as aggregates by SEC-LC, charge variants by AEX, HCP by CE-SDS, peptide mapping and intact mass analysis by LC/MS/MS, and protein quantitation by SoloVPE and other colorimetric assays.
    • Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data.
    • Strong interpersonal skills; ability to communicate effectively both verbally and in written formats.
    • Ability to work with minimum supervision in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Associate Director, Analytical Development
 
Location: San Carlos, CA
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $152,000 – $170,000
 
 

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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