Skip to main content

This job has expired

You will need to login before you can apply for a job.

Principal Scientist, Digital Pathology in Translational Pathology

South San Francisco, California
Start date
Apr 15, 2024

View more

Job Details


If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Principal Scientist, Digital Pathology in Translational PathologyLive

What you will do

Lets do this. Lets change the world. The use of Biomarkers and Diagnostics is central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Accordingly, the Clinical Biomarkers & Diagnostics (CBD) function plays a critical role in advancing our drug development programs and is accountable for the development of biomarker and diagnostics strategy across our pipeline. The Translational Pathology group within CBD is responsible for implementing the biomarker and diagnostics strategy. We are seeking a highly motivated individual to help drive digital pathology implementation including machine learning/artificial intelligence algorithms to support diagnostics and biomarker strategies. This individual will work closely with internal groups and external CROs/collaborators for digital pathology algorithm development and implementation.

In this vital role you will successfully partner with cross-functional stakeholders to drive implementation of biomarker and diagnostics assay development

  • The Digital Pathology Principal Scientist will be accountable for implementation of digital pathology including image analysis and artificial intelligence/machine learning (AI/ML) algorithms for clinical trial biomarkers including pharmacodynamic, mechanism of resistance, patient selection and biomarker discovery
  • The Digital Pathology Principal Scientist will provide subject matter expertise in tissue-based image analysis and artificial intelligence/machine learning (AI/ML) algorithms for application to clinical trial specimen whole slide images including providing QC/selection of H&E images and associated metadata, verification of vendor partner analysis, and strategic decision making in response to findings
  • The Digital Pathology Principal Scientist will be accountable for delivering internal and external image analysis and AI/ML solutions for clinical trial assays across therapeutic areas through management of individual contributors, cross-functional scientific and operational partners, and external partnerships

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a go-getter with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of digital pathology and AI/ML experience


Masters degree and 5 years of digital pathology and AI/ML experience


Bachelors degree and 7 years of digital pathology and AI/ML experience

Preferred Qualifications:
  • Experienced scientist with expertise in digital pathology and clinical applications of artificial intelligence/machine learning (AI/ML) and with relevant postdoctoral academic, clinical and/or industry pathology experience. PhD is a plus but not a requirement.
  • A proven digital pathology and artificial intelligence/machine learning (AI/ML) track record with credible publications
  • Demonstrated expertise in artificial intelligence/machine learning (AI/ML) clinical application
  • Expertise with human diseases across therapeutic areas
  • Working knowledge of histology and tissue-based assays such as immunohistochemistry
  • Expertise with image analysis software and algorithm design
  • In depth experience with the discovery, characterization, clinical validation and utilization of artificial intelligence/machine learning (AI/ML) :
  • Awareness of the challenges of implementing artificial intelligence/machine learning (AI/ML) technologies in the clinical setting
  • Direct experience in development, outsourcing and validation of clinically applicable artificial intelligence/machine learning (AI/ML) algorithms
  • Demonstrated excellence in independently leading and conducting research and ability to summarize information/data in a concise, easy to understand manner
  • Excellent verbal and written communication and presentation skills
  • High level of initiative and ability to work independently
  • High level of business awareness

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible
Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.


We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.

We live the mission.

We win together.

We thrive on continual challenge.

Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.

At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.

Connect with us to explore how you can Win, Live, and Thrive at Amgen.

Facebook  Social Icon - X Logo

Company info
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert