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Advisor - Statistics (Pre-Clinical Statistician)

Eli Lilly and Company
Cambridge, Massachusetts
Start date
Apr 11, 2024

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Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Brand Description:

At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Cambridge shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center works on the next generation of therapeutics including siRNA, ASO, gene editing, and nanoparticle deliver while offering a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.


  • The Project Statistician at the Advisor level provides statistical leadership in multiple dimensions including:

  • Provides technical leadership and expertise in initiating and carrying out multi-disciplinary or cross functional projects that impact the Lilly Research Laboratory and the Statistical Sciences organization

  • Leads the assessment and introduction of new statistical technology and methodology, including both frequentist and Bayesian techniques, to apply to broader practice

  • Leads the design and analysis of in-vitro and in-vivo experiments to advance the discovery portfolio in multiple therapeutic areas, innovative study designs, and statistical analysis plans in collaboration with biologists and other researchers

  • Provides consultation for specialized biomarker analyses including genomic analysis of RNA expression data and analysis of other biomarker data (single cell RNA, NGS, protein, imaging) in conjunction with pre-clinical and clinical data

  • Establish novel visualizations to explain complex results and interactions

  • Provides consulting and statistical direction on priority discovery projects

  • Statistical Design and Analysis:

  • Work with Drug Discovery teams to understand statistical needs to improve the quality of candidates and shorten drug development timelines. This will involve understanding the experimental objectives, appropriately specifying the primary and secondary endpoints, setting the sample size using statistical power analysis, determining appropriate statistical methods, and analyzing the data to determine the results. Engage in the write up of the results and presentations to Project and Scientific Management

  • Understand biological assay development needs and advise biologists on experiments required to validate biological assays for Drug Discovery programs. Experience with design of experiments and applications to high throughput screens will be valuable in this role.

  • Find opportunities for Meta-Analysis and other Data Mining techniques, and then conduct them, to identify key results from a series of experiments to identify key conclusions from the gestalt of all experiments in the program and determine appropriate next steps the Project Team should prioritize to optimize progress. This will require knowledge of in-house data repositories, knowledge about publicly available data sources and repositories, and the ability to use appropriate data management tools to build the necessary datasets and then to conduct the analysis

  • Develop and provide training courses on statistical methods for biologists, chemists, and other research staff

  • Potential leadership and direction of contracted statistical analyst support

  • Maintain currency with respect to statistical methodology, maintain proficiency in applying new and varied methods, and to be competent in justifying methods selected

  • Influence team members regarding appropriate research methods

  • Perform peer-review of work products from other statistical colleagues

  • Communication of Results and Inferences:

  • Collaborate with team members to write reports and communicate results

  • Assist with, or be responsible for, communicating study results via internal governance, manuscripts, or oral presentations in group settings, as well as for communicating one-on-one with key customers and presenting at scientific meetings

  • Respond to regulatory queries and interact with regulators

  • Therapeutic Area Knowledge:

  • Understand disease states, competitive landscapes, and the foundational science in order to enhance the level of patient focus and collaboration and be seen as a strong scientific contributor

Regulatory Compliance:

  • Perform work in full compliance with assigned curriculum(s) and will be responsible for following applicable Corporate, Medical, local, and departmental policies, procedures, processes, and training as well as ensuring legal, regulatory and data protection requirements are met in all activities

Statistical leadership and Teamwork:

  • Introduce and apply innovative methodology and tools to solve critical problems

  • Merge scientific thinking and business knowledge to identify issues, evaluate options and implement solutions

  • Lead projects independently and work effectively across functions. Apply technical expertise to influence business decisions

Basic Qualifications:

  • Ph.D. in Statistics or Biostatistics

Additional Preferences

  • Flexibility to locate to Boston, MA to join our growing team

  • Expertise and experience in study design, mixed models, multivariate analysis, design of experiments, multiplicity control, and analysis of variance

  • Proficient in statistical programming languages/software such as R, Python, SAS®, JMP®, etc.

  • Demonstrated problem solving ability and critical thinking

  • Interpersonal communication skills for effective customer consultation and collaboration

  • An established track record of developing and maintaining an area of statistical or collaborative research

Additional Preferences (a plus, but not required):

  • Experience with pre-clinical, biomarker, genomics/genetics, or discovery research data and analyses

  • Experience manipulating and analyzing large data sets

  • Knowledge or education in Biology

  • Skills in biological pathway/network analysis

  • Skills in predictive modeling and machine learning

  • Experience working in High-Performance Computing environment

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.



Science has been our calling from the beginning. Colonel Eli Lilly founded the company in 1876 and charged employees to “take what you find here and make it better and better.” More than 147 years later, we remain committed to his vision through every aspect of our business and the people we serve, starting with discovering the best treatments for those who take our medicines and extending to health care professionals, employees and the communities in which we live. Moreover, you can also count on the team at Lilly to be incredibly civic-minded, supporting our communities through philanthropy, volunteerism, and a creative and innovative can-do spirit. 

Company info
893 S Delaware St
United States

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