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Staff Systems Engineer

Eikon Therapeutics
Hayward, CA
Start date
Apr 7, 2024

Job Details

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.


We are seeking a dedicated and experienced Staff Systems Engineer to play a critical role in developing and productizing Eikon’s platform. This platform is Eikon Therapeutics’ revolutionary system that tracks thousands of protein movements simultaneously to measure biological behavior. AI is then applied to these tracked protein movements to give scientists insight into the biological processes. As a Staff Systems Engineer on the platform development team, you will play a central role in the commercial success of a super-resolution imaging system using your technical expertise and interpersonal skills. You will guide development of system and subsystem architecture and design by understanding the relationship between design and user needs. You will need to understand the big picture while navigating and resolving issues at the detail-level. In this role, you will drive key architectural, design, and interface decisions. You will also contribute to our understanding of our design through hands-on characterization and verification.   

About You 
The ideal candidate should bring extensive experience developing opto-electro-mechanical systems and have launched products; have experience in systems definition, systems integration, and systems verification; and have excellent problem-solving skills and the ability to analyze complex technical issues to determine effective solutions. Eikon Therapeutics has a strong team spanning science, engineering, and data science.  Strong communication and collaboration skills are necessary for working with this diverse team and stakeholders. The person in this position will work on multi-disciplinary problems and will need to drive decisions and issue resolution.  A passion for contributing to the convergence of biology and technology through exceptional engineering is a plus.  

What You’ll Do 

  • Create and manage requirements from system level and below. 
  • Create and manage FMEA and Hazard Analysis. 
  • Drive system integration builds, debugging, and testing. 
  • Create and execute Characterization Plan to characterize the system as well as subsystems. 
  • Create and execute Verification Test Plans and Test Protocols.  
  • Develop testing capabilities to enable characterization and verification including developing test methods, test scripts, and test fixtures. 
  • Develop an understanding of how the system works and the interdependencies within the system. 
  • Failure root cause analysis. 
  • Coordinate certification testing to comply with national and international standards and regulations.   
  • Guide engineering team to comply with standards and regulations. 
  • Support transfer to manufacturing. 
  • Support sustaining the product. 
  • Work with a diverse team of engineers and scientists to resolve issues and innovate.  
  • Facilitate and drive trade-off analysis including design decisions and component selection. 
  • Help define and improve Systems Engineering practices and processes. 
  • Educate engineering team on best systems engineering practices. 
  • Proactively identify opportunities for system enhancements, optimizations, and improvements. 


  • Bachelor’s degree with 8 years of relevant experience or a Master’s degree with 6 years of relevant experience or a PhD with 3 years of relevant experience in Optical Engineering, Electrical Engineering, Mechanical Engineering, or a related field. 
  • Strong fundamentals in one of the Engineering or Applied Science disciplines. 
  • Completed at least one product development cycle and experience sustaining a product. 
  • In-depth experience creating systems requirement and decomposing systems requirement into lower-level requirements and seeing it through verification. 
  • Experience creating risk analysis of systems with electrical, mechanical, optical, and software components and coming up with proper risk mitigations.   
  • Experience working with a cross-functional team to plan and execute integration builds, including hands-on troubleshooting and resolving build issues. 
  • In-depth experience creating and executing verification plans and protocols. 
  • Experience creating test setups, including designing test fixtures, building opto-electro-mechanical equipment, and creating instrumentation and data acquisition setups.   
  • Hands-on experience and/or experience leading a team to root cause failures. 
  • Ability to analyze data using tools such as Excel, JMP, MiniTab, Python, and/or MATLAB.  Have used hypothesis testing to draw conclusions. 
  • Experience working with National Recognized Test Laboratories to get certification for electrical safety. 
  • Strong communication and collaboration skills for working with diverse teams and stakeholders. 
  • Desirable skills and experience: Six sigma, gage R&R, microscopy, and/or AI. 

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:​

  • 401k plan with company matching​
  • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)​
  • Mental health and wellness benefits​
  • Weeklong summer and winter holiday shutdowns​
  • Generous paid time off and holiday policies​
  • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies ​
  • Enhanced parental leave benefit​
  • Daily subsidized lunch program when on-site​

The expected salary range for this role is $163,000 to $178,600 depending on skills, competency, and the market demand for your expertise.


Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company’s duty to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA’s emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California’s Fair Employment and Housing Act, you will need to contact the Company’s Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as recommended by the Centers for Disease Control and Prevention.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.


Eikon is a pioneering drug discovery and development company that leverages superior engineering and high-performance computing to analyze single molecule protein behavior in living cells. We are engineering a battery of innovative tools and technologies for biological exploration in drug discovery and beyond.

Eikon thrives on the energy and creativity of interdisciplinary teams. We are physicists and chemists, biologists and engineers. We spend our days context-switching between multiple scientific languages. We work with lasers, super-resolution microscopes, and robot arms. We leverage machine learning, cell line engineering, and the collective intelligence of world-class scientists and technologists to observe therapeutically relevant biology in a way no one has before.

We’re endlessly curious, intellectually honest and we love what we do. We’re driven to learn the true mechanisms of biology and pharmacology at the molecular level, to make the biggest difference in as many lives as possible.

Company info
3929 Point Eden Way

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