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Sr. Associate Engineer, Polysaccharide Process Development

Vaxcyte, Inc.
San Carlos, California
Start date
Apr 5, 2024

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Engineering, Manufacturing & Production, Process
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay

Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Essential Functions:
    • Assist in designing and executing process development runs focusing on scale down modeling and late-stage process characterization of upstream and primary recovery steps.  
    • Operate and maintain instrumentation including BSL2 microbial fermenters, TFF systems, depth filtration and centrifugation.
    • Record data in electronic laboratory notebooks, and aid in writing technical summary reports.
    • Perform analytical assays for process development and in-process manufacturing samples and maintain manufacturing and process development data repositories.
    • Perform statistical analysis for manufacturing in-process data for manufacturing process insights and characterization purposes.
    • Present data to the team to provide updates on small scale development activities and contribute to technical discussions.
    • Perform scaling calculations between large scale manufacturing and small-scale process development operations.
    • Review manufacturing documents and transfer in-process data to data repositories.

    • B.S./M.S. in bioengineering, chemical engineering, biochemistry or other related disciplines with 3+ years of experience.
    • Prior experience with bioreactor fermentations, including glass and single use vessels, as well as experience with depth filtration, centrifugation, and TFF for primary recovery.
    • Experience with analytical methods such as plate-based assays, UV-spectrophotometry, and metabolite analyzers.
    • Experience writing technical documents including lab operation protocols and data summary reports.
    • Proficiency in computer programs including Microsoft Excel, Word, and Powerpoint.
    • Experience with statistical software such as JMP, R studio, python, etc. for manufacturing process analytics.
    • Familiarity with statistical methods for process characterization and validation is a plus.
    • Familiarity with DOE principles and experience with DoE software (JMP) is a plus.
    • Some experience with GXP requirements including deviation investigations, CAPAs, and change controls.
    • Understanding of engineering principles for scaling upstream unit operations.

Reports to: MSAT Engineer II, Polysaccharide
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $107,000 – $123,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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