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Sr. Associate Engineer, Pilot Plant

Vaxcyte, Inc.
San Carlos, California
Start date
Apr 3, 2024

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Science/R&D, Biology, Biomedical Sciences, Chemistry
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay

Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

We are seeking a motivated candidate to join our Pilot Plant operations team and support the design, construction, commissioning and operation of a new state-of-the-art facility. This facility will serve as a major technical hub of the business and will support execution of process characterization, validation studies as well as new technology evaluations as deemed necessary. Once the facility is online, you'll be responsible for routine pilot plan operations as well as contribute towards future plant expansion projects. The position will provide an opportunity for learning and development in a professional lab setting, contributing to development and commercialization of our company's life-saving therapeutics. The primary responsibility for this position will be the support of the pilot plant operations team with secondary opportunities to support the MSAT team.
The ideal candidate should have experience with small - scale and/or large - scale bioprocess equipment, including stainless steel and single use mixing tanks, bioreactors, sterile filtration, chromatography systems, aseptic technique and be able to work well with others, communicate effectively both written and orally. Candidates may be requested to work during non-business hours/days to support extended growth and production activities.
Essential Functions:
    • Actively support routine pilot plant operations.
    • Batch documentation within an electronic laboratory system.
    • Participate in scheduling discussions within the operations team.
    • Work collaboratively with process development scientists, MSAT colleagues and external partners as necessary.
    • Support safety and training initiatives.
    • Employs good housekeeping and helps manage materials supply chain as required for seamless PP operations.

    • BS in Chemical/Biochemical/Biomedical Engineering/Biology/Chemistry or related discipline with 5+years of industry experience, Masters with 3+years of relevant experience.
    • Strong skills in laboratory experimentation and documentation.
    • Strong communication and interpersonal skills to work in cross-functional team environments.
    • Lead technical projects or sub-teams including vendor interactions.
    • Strong troubleshooting skills.
    • Ability and willingness to learn new lab techniques, adhere to all safety guidelines, and pick up/move up 25lbs.
    • Basic computer skills including Microsoft Office with proficiency in Power App, Power BI, Word, and Excel.

Reports to: Director, Protein Development and Clinical Manufacturing
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $111,000 – $126,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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