Skip to main content

This job has expired

You will need to login before you can apply for a job.

Principal Scientist / Associate Director / Director - Mammalian Cell Line Development

CHO Plus
South San Francisco, CA
Generous employee stock option plan and paid time off (PTO) and comprehensive health insurance.
Start date
Mar 28, 2024

View more

CHO Plus was founded to address the high costs and production capacity limitations faced by biologics manufacturers (therapeutic proteins and viral vectors for gene therapy). Our technologies for creating and improving cell lines will lead to processes with significantly higher productivity while cutting the costs of manufacturing and building expensive new factories. Our engineered cell lines will be accepted by regulatory agencies and they will provide improved performance (higher productivity) at a cost similar to accepted industry standards. For further information – visit:

This senior-level molecular/cellular biologist position is for someone who will help CHO Plus disrupt biologics (protein and viral vector) production, and be motivated to further develop our technologies toward full commercialization. The successful candidate will bring significant experience in cell line development for protein (via CHO) or viral vector (via HEK-293) production. They must work independently on the bench, as well as supervise junior lever scientists.

The position is full time, and is based at the company’s headquarters in South San Francisco. Flexibility regarding working hours and business travel is required.


  • Host cell line engineering
  • Vector design and construction
  • Transfection, mammalian cell culture, cloning and screening
  • Flow cytometry, PCR, and other related molecular and cellular biology techniques
  • Developing and performing protein and viral vector assays for screening and analysis for characterization and quality of cells and products
  • Performing lab work and supervising mid-level scientists
  • Collaboration with co-workers, and with external partners and collaborators


  • PhD in a related field, or an equivalent amount of experience
  • Experience with mammalian cell line engineering, preferably for one or more pharmaceutical companies
  • Mammalian cell culture expertise for production of recombinant proteins or viral vectors
  • Experience with general molecular biology techniques for designing and constructing vectors, transfecting mammalian cells, and evaluating cell genetics


  • Experience with flow cytometry and photomicroscopy
  • Experience with transposase and other transfection methods
  • Experience with cell banking
  • Knowledge of the regulatory environment related to creating and testing cells destined for GMP manufacturing


  • Generous employee stock option plan and paid time off (PTO)
  • Comprehensive health insurance


Ramani Aiyer

Chief of Staff

Mobile: +1 (925) 470-7850

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert