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Associate Scientist, Early Preclinical Development - Inner Ear Biology

Employer
Eli Lilly and Company
Location
Boston, Massachusetts
Start date
Mar 27, 2024

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Discipline
Science/R&D, Biology, Biotechnology
Required Education
High School or equivalent
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Akouos, a wholly owned subsidiary of Eli Lilly and Company, is building a leading gene therapy company focused on hearing disorders. We are a precision genetic medicine company focused on developing gene therapies with the potential to restore, improve, and preserve high-acuity physiologic hearing for individuals who live with disabling hearing loss worldwide.

Restoring, improving, and preserving high-acuity hearing is an area of high unmet need in medicine: 466 million people worldwide have disabling hearing loss, and there are no FDA-approved pharmacologic therapies to address its underlying causes.

Akouos was founded in 2016 by leaders in the fields of neurotology, genetics, inner ear drug delivery, and AAV gene therapy. Listening is in our DNA. We believe the only way to achieve our ambitious goals is to engage as one team, listen to each other, and trust in ourselves and our science.

The Early Preclinical Development (EPD) Team is seeking an Associate Scientist with experience in inner ear histology to support discovery and IND-enabling animal studies. The ideal candidate will have experience in histologic techniques specific to the inner ear, such as microdissection of the mouse and non-human primate (NHP) inner ear tissues into discrete anatomical regions, and further processing of these tissues using various histologic techniques, in addition to imaging, analysis, and preparation of data for presentation. Cross-functional work may be required to advance Company goals. The successful candidate will be self-motivated and creative, with a desire to succeed at the highest level in a highly collaborative and fast-paced environment.

Job Responsibilities:

  • Perform mouse and NHP inner ear microdissections
  • Perform NHP temporal bone extraction and processing
  • Prepare inner ear tissues for embedding and preparation for frozen sections
  • Preparation of inner ear tissues for molecular analyses
  • Perform immunohistochemistry
  • Perform epifluorescent imaging, cochlear frequency mapping, and confocal microscopy
  • Produce graphs and charts from histologic data
  • Preparation of histologic images for presentation
  • Development and/or review of immunohistochemistry protocols
  • Inventory ordering and database management
  • Collaborate closely with cross-functional teams and external groups to coordinate and drive complex studies
  • Weekend work may be required at times

Basic Qualifications:
  • Bachelor's Degree with 0+ years of experience, or high school diploma and 2+ years of hands-on experience with inner ear biology.

Additional Skills and Preferences:
  • Experience in solving scientific problems and/or image analysis using programming languages
  • Experience and programming skills in at least one language such as Python or MATLAB
  • Knowledge of cochlear anatomy, cochlear microdissection (whole-mount and sections), and methods for histological preparation of inner ear tissues required
  • Experience with modern imaging techniques; epifluorescent and confocal microscopy required
  • Excellent computer skills; proficiency in Microsoft Office (Word, Excel, Teams, PowerPoint, Outlook, Adobe Suite)
  • Experience with image analysis software (ImageJ, Amira, LasX, Imaris); may include coding
  • Excellent laboratory technical lab skills (pipetting, reagent preparation, liquid handling)

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

#WeAreLilly

Company

Science has been our calling from the beginning. Colonel Eli Lilly founded the company in 1876 and charged employees to “take what you find here and make it better and better.” More than 147 years later, we remain committed to his vision through every aspect of our business and the people we serve, starting with discovering the best treatments for those who take our medicines and extending to health care professionals, employees and the communities in which we live. Moreover, you can also count on the team at Lilly to be incredibly civic-minded, supporting our communities through philanthropy, volunteerism, and a creative and innovative can-do spirit. 

Company info
Location
893 S Delaware St
Indianapolis
Indiana
46285
United States

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