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Staff Research Scientist - Imaging Engineer

Gladstone Institutes
San Francisco, CA
Start date
Mar 26, 2024

View more

Regulatory, Science/R&D, Biotechnology, Research
Required Education
Position Type
Full time
Biotech Bay

Job Details

Lab/Area:Akassoglou Lab


The Akassoglou Lab at The Gladstone Institutes is seeking a highly skilled imaging-oriented engineer to join our group as a Staff Research Scientist-Imaging Engineer. The mission of the position is to develop technologies to investigate the interactions between the immune, vascular and nervous systems with the aim to understand dynamic biological processes and decipher the sequence of events and their causative relationship that lead to disease and utilize these tools to design and test effective treatments. For recent publication on microglia in brain network hyperexcitability see Merlini et al., Nat Neurosci Nat Neurosci24,19–23 (2021). The person in the position will be responsible for the following:

  • Plan, design, initiate, interpret and report experiments using repetitive two-photon imaging and confocal microscopy in the living mouse brain and spinal cord

  • Lead the development and implementation of new technologies and protocols for advanced in two-photon imaging applications (e.g. functional imaging, labeling methods)

  • Develop new projects and support ongoing research projects

  • Establish in-house expertise in animal models reporters relevant to intravital imaging

  • Project management of research collaborations, including technical training of new personnel, supervision of two-photon microscopy experiments, administrative tasks

  • Assist with processing, analysis and interpretation of imaging data

  • Develop code/scripts for image analysis and acquisition pipeline

  • Screen and test novel imaging-based instrumentation

  • Develop grant applications for purchase of new equipment, personnel support, and collaborative grant applications

  • Day-to-day maintenance of imaging set-ups, including laser equipment

  • Work and communicate effectively with collaborators, as well as administrative departments and IT

  • Ensure compliance with relevant regulatory guideline with EH/S and IACUC


  • PhD in Bioengineering, Physics, Neurobiology, Physiology, Immunology or related fields with at least 3 years postdoctoral experience in a biomedical and/or research and development environment

  • At least 2 years of in vivo imaging experience

  • In depth knowledge of optics, fluorescence microscopy, and live imaging of biological material. Rodent handling and surgical experience essential.

  • Expertise in developing and implementing new imaging modalities and customized software tools for 4D image data analysis (Image J, FluoView, Imaris, Volocity).

  • Computational skills in bioinformatics are required (R, MATLAB, Python)

  • Strong research interest in neuroimmunology, neurodegeneration, and cell biology

Preferred skills:

  • Experience with genomics

Hiring range (DOE):

$93K - $150K

Additional Information:
  • Title and salary will be commensurate with education and experience.
  • Gladstone is an equal opportunity employer.


Gladstone is an independent, nonprofit life science research organization located in the epicenter of biomedical and technological innovation in the San Francisco Bay Area. Gladstone has created a research model that disrupts how science is done, funds big ideas, and attracts the brightest minds. Gladstone Institutes leads the way for innovative research in the biomedical field. We always seek dedicated and talented individuals to join our team.

Scientists know that using a diversity of approaches is often the most efficient strategy for solving a problem. New and different perspectives engender the very innovation that Gladstone prizes. This is one of the many reasons why we value diversity at Gladstone—be that a diversity of race, culture, religion, mental or physical ability, heritage, age, gender, sexual orientation or other characteristics. Our employees hail from more than 30 countries around the globe and we seek to hire the best and brightest for our diverse team of scientists and administrators. Career opportunities are available in both our administrative offices and our research areas.

Our Benefits
Gladstone offers eligible employees—and their dependents—a comprehensive range of benefits, including health insurance, retirement savings, and professional development.


  • Health and Retirement
    • A choice of medical plans, flexible spending account, and retirement account options that include employer contributions help you take care of your health and your future.
  • Time Away from Work
    • More than just vacation days, our paid and unpaid leave policies offer flexibility to help you confront different stages of life including maternity and paternity leave, as well as other types of family leave.
  • Professional Development
    • Gladstone encourages employees to seek the skills they need to remain at the forefront of their profession. By supporting professional development workshops and continuing education, Gladstone provides employees with the resources they need to evolve in their role and in their career.
  • Gladstone Cares
    • A specially selected suite of benefits to support you in and out of the workplace. Includes resources for dealing with the many stages of life to specific coverage for family planning, and back-up child or elder care coverage.
Company info
1650 Owens Street
San Francisco

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