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Principal Scientist, Biomarker Sciences

Avidity Biosciences
San Diego, California
Start date
Mar 25, 2024

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Science/R&D, Biotechnology
Required Education
Position Type
Full time
Biotech Beach

Job Details

Job Title:

Principal Scientist, Biomarker Sciences


San Diego and Remote

Position type:


Full time



Development Sciences

Strive to Bring a Profound Difference to our Patients

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit and engage with us on LinkedIn and Twitter.

The Opportunity

We are seeking a seasoned translational scientist to join the biomarker team at Avidity Biosciences in La Jolla, CA.  Experience with clinical biomarker development, data analysis and regulatory interactions is required.  The ideal candidate will be a strategic and critical thinker responsible for developing and implementing biomarker strategy to demonstrate drug activity in first-in-human studies.  Strong communication skills and the ability to work in cross-functional project teams are required. The primary role will be to develop and implement Biomarker Research plans for preclinical and clinical-stage programs. The ideal candidate should enjoy scientific research and collaboration in a fast-paced, interdisciplinary environment.

What You Will Contribute

  • Lead the development and execution of clinical biomarker strategy to demonstrate pharmacodynamic activity and mechanism of action in FIH studies. Partner with development teams on how to utilize biomarker data to support dose selection for Phase 2/3 studies.
  • Accountable for assay development, validation and analysis of clinical biomarker data by collaborating with internal stakeholders and external CROs.
  • Responsible for the interpretation of biomarker data and communication to project teams/senior management.
  • Become a trusted member in cross-functional program teams and lead biomarker sub-teams to achieve overall program goals and timelines.
  • Responsible for the biomarker-related sections in clinical and regulatory documents (e.g., clinical protocols, ICFs, INDs, IBs, CSRs).
  • Establish collaborations with academic labs/KOLs to support Avidity’s drug pipeline.
  • Work closely with research teams to identify and develop biomarkers associated with disease progression, drug response and patient selection to support IND.
  • Mentor scientists within Research and Development on biomarker strategy and implementation.

What We Seek

  • PhD in Biology, Pharmacology or related disciplines; minimal of 6 years of industry experience with significant hands-on experience in translational medicine and biomarker development..
  • Experience with assay development and analysis of multi-omics data.
  • Excellent communication and interpersonal skills, problem-solving skills, strategic and independent thinking.
  • Must demonstrate a high level of independence and the ability to develop hypotheses and direct analysis plans.
 What We will Provide to You:
  • The base salary range for this role is $173,000 - $194,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
  • Avidity offers competitive compensation and benefits which includes the opportunity for annual and spot bonuses, stock options and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and four weeks of time off.
  • A commitment to learning and development which includes a variety of programming internally developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

Avidity Biosciences

10578 Science Center Dr. Suite 125

San Diego, CA


O: 858-401-7900

F: 858-401-7901



avidity banner

Our vision is to profoundly improve people’s lives by revolutionizing the delivery of RNA therapeutics. We’re utilizing our proprietary AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) with the precision of oligonucleotide-based therapies in order to redefine RNA therapeutics and more effectively target underlying genetic drivers of diseases. We are delivering on this vision by investing in our platform, our pipeline and our people.

Our commitment to rigorous and innovative science is matched only by our passion to see patients’ lives changed. We consistently challenge ourselves to Be AVID – Agile, Visionary, Integrated and Diverse.

We are assembling a diverse team experienced in rare disease and RNA therapies. Our team members bring expertise in research, development and commercial execution. We are focused on cultivating the right team to not only grow the company, but also to reflect the communities we serve. We are dedicated to employing and retaining a diverse and inclusive workforce at all levels of the organization to not only ensure that different backgrounds and perspectives are being heard and acted upon, but that our employees also feel understood, accepted and valued.


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Company info
10578 Science Center Drive
Suite 125
San Diego

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