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Sr. Associate Engineer, Polysaccharide Downstream Pilot Plant

Vaxcyte, Inc.
San Carlos, California
Start date
Mar 20, 2024

View more

Administration, General
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay

Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Vaxcyte is looking for an energetic and talented Sr. Associate Engineer to contribute to the Polysaccharide Downstream Pilot Plant function within the CMC team. Vaxcyte is developing a multi-valent polysaccharide-based conjugate vaccine, based on a novel carrier protein produced using the Xpress CF platform. Polysaccharides are a critical component in conjugate vaccines.
The successful candidate will have practical laboratory experience related to biotechnology, biopharmaceuticals, or vaccine industries, particularly around purification of macromolecules.
The candidate will be eager to utilize and learn new laboratory skills as this person will be responsible for collaboration on experimental design and execution of experiments at pilot scale for scale down modelling efforts and manufacturing program development. This position will require >50% time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate will write detailed technical reports, present experimental results internally, and potentially interface with external CMO partners.
Essential Functions:
    • Perform downstream pilot scale experiments within DSP operations, focusing on the scale down model of the current manufacturing process, including all related set-up operations of buffer preps.
    • Operate and maintain instrumentation for polysaccharide purification including Akta chromatography skids, TFF system, depth filtration systems, and centrifuges.
    • Perform analysis and interpret results for polysaccharide and impurity assays (Anthrone, Lowry, SEC-MALS, HPAEC-PAD etc.).
    • Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic notebooks.
    • Authoring/development of experimental protocols prior to experiment execution and respective results and reports.
    • Present/communicate data to polysaccharide team.
    • Contribute to technical discussions within the polysaccharide team.
    • Works within a team environment and provides support as necessary to further the team’s initiatives.

    • Senior Associate Engineer: BS in Chemical Engineering, Biochemistry, or a related discipline, with 5+ years of industry experience; MS with 3+ years of industry experience.
    • Practical experience in supporting/execution of bioprocess operations such as Chromatography, TFF, depth filtration, and continuous centrifugation with a strong experience in 1 area.
    • Demonstrated understanding/proficiency with engineering principles involved in scaling processes and transferring processes (lab, pilot, manufacturing).
    • Experience in writing experimental protocols and summary reports.
    •    Benchling experience is a plus.
    • Familiarity with DoE (Design of Experiments) principles and ability to perform statistical data analysis with collected data.
    •    Process characterization experience is a plus.
    • Working knowledge of the requirements of GxP standards.
    • Demonstrated success working in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver results.
    • Strong interpersonal skills, with excellent written and verbal communication skills.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Associate Director, Polysaccharide Pilot Plant and Manufacturing
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $107,000 – $123,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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