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Senior Manager, Competitive Intelligence

Employer
4D Molecular Therapeutics
Location
Emeryville, California
Start date
Mar 18, 2024

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Job Details

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.

 

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.  

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators: 

•    Fully integrated clinical-phase company with internal manufacturing
•    Demonstrated ability to move rapidly from idea to IND
•    Five candidate products in the clinic and two declared pre-clinical programs
•    Robust technology and IP foundation, including our TVE and manufacturing platforms
•    Initial product safety and efficacy data substantiates the value of our platforms
•    Opportunities to expand to other indications and modalities within genetic medicine

General Summary 

The Senior Manager of Competitive Intelligence is a key contributor to competitive planning efforts that shape the company’s commercial and development strategies. This individual will be a crucial strategic thought partner to key internal stakeholders throughout the organization. This individual will be responsible for leading and managing primary and secondary competitive intelligence activities and will work closely with multiple cross-functional teams. This individual will also lead and support strategy analyses in support of cross-functional teams including commercial, clinical, IR and business development.  

 

RESPONSIBILITIES: 

Competitive Intelligence: 70% of TIME 

  • Define and lead CI processes that meet the evolving needs of cross-functional stakeholders. Proactively anticipate competitive milestones and evolving industry dynamics. 
  • Organize CI activities, including scoping and overseeing vendor support as appropriate. 
  • Lead planning for key industry, medical, and broker conferences  
  • Define yearly schedule and drive working team preparedness  
  • Attend key scientific congresses and summarize key insights from a scientific perspective focusing on novel treatment paradigms, mechanisms of action, and clinical trial landscape.
  • Communicates conference coverage insights (oversees which meetings to attend, which presentations to flag, drives CI writeups)
  • Cover competitor earnings and key investor calls, providing summaries of key metrics and implications in a timely manner
  • Consistently and effectively communicates with key stakeholders to inform on timely alerts (e.g. clinical data releases, product approvals/failures) and landscape updates with commercial implications
  • Develop and maintain accessible competitive summaries and analyses across the portfolio
  • Lead  and manage the collection and analysis of information from other teams at 4DMT (Clinical, IR)
  • Proactively anticipate cross-functional needs
  • Take the initiative to partner with peers across business functions to gather and analyze data
  • Achieve visibility across teams within the company
  • Generate reports, dashboards and analyses for company executives to  support strategic decision making, including portfolio and pipeline management and business development activities 

Strategy Analysis: 30% of TIME 

 

  • Support insight generation and competitive scenarios to aid with forecast models and strategic plans, including risks and opportunities, and alternate scenarios 
  • Research relevant and emerging technologies of interest and understanding the impact on our business 
  • Translate data and information into compelling insights and recommendations. Effectively communicate insights and lead meetings with commercial leaders and other cross functional business partners 
  • Lead and support analytics required to generate and triangulate insights across data sources, including primary market research, secondary literature and other data sources, as available 
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time 

 

QUALIFICATIONS: 

 Education: 

  • Advanced degree in a relevant life science discipline. 

Experience: 

  • Minimum of 2-3 years work experience, preferably with specific biopharma competitive intelligence responsibilities and/or with a life science consulting firm. 
  • Demonstrated understanding of the pharmaceutical product development lifecycle 
  • Prior knowledge about the workings of clinical trials 
  • Understanding of biotech market 
  • Knowledge of biology behind disease manifestations 
  • Demonstrated excellence in communication as related to writing, analysis and presentation 
  • Experience with primary intelligence and secondary data sources is highly desirable 
  •  Expertise in ophthalmology and/or gene therapy is preferred 

 Skills 

  • Advanced or Expert level in Microsoft Office: Excel, Powerpoint, Word, Outlook  
  • Qualitative and quantitative databases and analysis 
  • Project oriented (have full autonomy over specific topics and job duties)  
  • Analytical mindset 
  • Growth mindset, flexible to take on new assignments in a dynamic environment 

Base salary compensation range:

Bay Area Range: $150,000/yr - $190,000/yr

National Range: $131,000/yr - $167,000/yr

Please note that compensation varies based on a variety of factors including experience, location, etc.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.   Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Company

4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.


At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.


While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.


At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.


4D Purpose Statement:  Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients


GUIDING PRINCIPLES

 

  • Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
  • Break Boundaries - Question the status quo and innovate beyond conventional approaches
  • Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
  • Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans


We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development. 
 

Company info
Website
Phone
510-505-2680
Location
5858 Horton St. Suite 455
Emeryville
California
94608
United States

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