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Associate Scientist II, Clinical Serology

Employer
Vaxcyte, Inc.
Location
San Carlos, California
Start date
Mar 15, 2024

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Discipline
Clinical, Clinical Research, Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
 
Summary:
 
Vaxcyte is looking for an energetic and talented Associate Scientist II to manufacture and test all reagents required for immunoassay detection of multi-valent vaccines. In particular, the reagents we are using need to be conjugated to different entities and then characterized and catalogued for our multiplexed assays. Extreme control of this assay is required to maintain DS shelf life and more importantly, ensuring DP compounding is successful in relation to the final dose of each DS in the clinic.
 
We require an Associate Scientist II who will continue the development and optimization of assay suites for our current 3 programs, and for upcoming research projects. This person will be part of a larger team that will continue this development.  The role requires an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities. In addition, the successful candidate will require significant experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen. 
Essential Functions:
    • Help continue the development and optimization of assay suites for our current 3 programs, and for the following research projects.
    • Have an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities.
    • Demonstrate experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen.

Requirements:
    • BSc/MSc 3-6 + years in Molecular Biology, Chemistry, Analytical Chemistry, Organic Biochemistry considered, or equivalent combination of education and experience.
    • Ideal candidate will have a significant background in plate-based assay development and antibody characterization including HPLC and Octet.
    • Experience in protein analysis such as SEC, HPLC, SDS-page, CE-SDS, and cIEF and binding kinetics is a plus.
    • Having a high degree of organizational capabilities for both reagents and experimental
    • scheduling a must.
    • Prior experience of transferring methods to external partners for validation and GMP activities will be of a significant benefit, and first-hand experience of a QC environment would also be advantageous.
    • Experience in immunoassay development, qualification, validation, trouble shooting and aiding in OOS investigations is highly desired.
    • The ability to present complex data sets and independently propose and design follow-up
    • experiments are also required.
    • Maintaining good laboratory practices, safety and record keeping for them-selves and their team is required.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Group Leader, Nonclinical and Immunoassay
 
Location: San Carlos, CA
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $105,000 – $114,000
 
 

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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