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Senior Scientist I - Process Engineering

Lake County, Illinois
Start date
Feb 26, 2024

Job Details

Process Engineering, a part of AbbVie R&D’s Development Sciences organization, is responsible for designing and developing scalable processes to make small molecule drug substances and drug products, including antibody drug conjugates (ADCs), throughout pre-clinical and clinical development stages. Process Engineering also partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins and cosmetic active ingredients (CAIs). We create valuable intellectual property through the composition of matter, chemical processes, and technologies resulting in cost-effective commercial manufacturing processes. We support the development of the supply chain for pipeline molecules and help prepare and defend CMC regulatory content.


Chemical/Bio Engineers support pipeline projects through all phases of development. Early in development, engineers focus on ensuring that the process can be run safely, identifying and addressing scale-up issues. Later in the development process, engineers optimize the drug substance and drug product processes and lead process campaigns. In the final stage of development, engineers transfer the optimized process to manufacturing sites, develop control strategy, prepare reports to support regulatory filings, and support process validation.


Role Overview

The successful neurotoxin and aesthetics engineering candidate will play a key role in the BioProcess Engineering (BPE) Center, a part of the Process Engineering function. The core deliverable of BPE is to develop robust processes to manufacture ADCs, toxins, CAIs, and biologics drug products utilizing strong engineering fundamentals.  The ideal candidate will have prior biologics process development and a passion for hands-on laboratory process development.  The candidate is also expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects and participate in a cross-functional team to deliver specific project needs.



Key Responsibilities:

  • Develop robust scale up and manufacturing processes, supporting neurotoxin and aesthetics assets through all phases of development. 
  • Perform laboratory experiments and process modeling to support process understanding and optimization.
  • Address challenging problems with biochemical reactions, fermentation, separations, and/or isolations using expertise in reaction kinetics, transport phenomena, and mathematical modeling. 
  • Author and/or review technical documents summarizing process development efforts.
  • Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively by maintaining strong working relationships with functions within Small Molecule CMC, Biologics CMC, and the broader CMC team. 

  • Qualifications:

  • BS, MS, or PhD in Chemical/Bio Engineering or a related field and 10+ (BS), 8+ (MS), or 0+ (PhD) years of relevant industrial experience.
  • Job level will be commensurate with academic and/or industrial work experience.
  • Candidates are expected to have a strong background in chemical engineering and the proven ability to demonstrate their skills in this field.
  • The candidate is required to possess effective oral and written communication skills and be a strong team player.
  • Preferred:

  • Biologics process development experience, particularly designing and scaling up of bioreactor and purification processes for protein therapeutics.
  • Working knowledge of analytical techniques such as HPLC, FTIR, Raman, and microscopy. 
  • Experience with laboratory experimentation and process scale-up.
  • Familiarity with operation of chemical/biochemical process equipment and systems.

    Key Leadership Competencies:

  • Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the “essence”, and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and enables innovation to reality.
  • AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    1 North Waukegan Road
    North Chicago

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