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Scientist I Analyt Chem

South San Francisco, California
Start date
Feb 26, 2024

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay, Best Places to Work

Job Details

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development.  Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure.


We have an exciting opportunity available for a Scientist I to join the CMC Biologics Analytical Research and Development group at AbbVie, located in South San Francisco, CA. In this lab-based role, you will utilize your knowledge of protein analytical chemistry and expertise in a variety of electrophoretic and high-performance liquid chromatographic (HPLC) methods to enable CMC development of AbbVie’s growing pipeline of clinical stage complex biotherapeutics, which include novel bispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will be responsible for supporting the development, qualification, transfer, and validation of analytical methods for the analysis and characterization of clinical stage complex biotherapeutics.



·       Develop electrophoretic and chromatographic methods to support development of therapeutic antibodies, antibody variants, and antibody drug conjugates (ADCs).

·       Perform capillary electrophoresis (CE) and HPLC testing to quantify product quality attributes and characterize biotherapeutic proteins.

·       Develop innovative approaches to solve difficult analytical challenges.

·       Develop, validate, and transfer fit-for-purpose QC release and stability methods.

·       Provide technical support for QC testing occurring at internal and external GMP laboratories.

·       Author technical documents (e.g. methods, protocols, reports), scientific publications, presentations, and regulatory documents.

·       Present work and results in team and group meetings.


    ·       BS in Chemistry, Biochemistry or related field with 5+ years of experience in the biopharmaceutical industry or MS with 2+ years experience.

    ·       Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.

    ·       Demonstrated proficiency in developing and performing protein capillary electrophoresis (CE-SDS), HPLC (e.g., SEC, IEX, HIC), and other separation methods as applied to protein analysis.

    ·       Capillary electrophoresis and HPLC method development, qualification, and validation expertise is desirable.

    ·       Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins.

    ·       Proven record of technical/scientific achievement and innovation.

    ·       Ability to learn new techniques, create and maintain accurate and complete records, adhere to laboratory SOPs, and exhibit attention to detail.  

    ·       Must have strong scientific writing and verbal communication skills.

    ·       Must be capable of working in a fast-paced, collaborative environment and managing multiple concurrent assignments with a high degree of independence.

    Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

    ·      The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

    ·      We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

    ·      This job is eligible to participate in our short-term incentive programs. 

    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

    AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    1 North Waukegan Road
    North Chicago

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