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Head Computational & Systems Biology, Senior Director Early Clinical Development and Biomarker

Cambridge, Massachusetts
Start date
Feb 24, 2024

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Job Details

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Head Computational & Systems Biology (C&SB), Senior Director where you will lead the ECD GI² TAU C&SB team with accountability for establishing C&SB strategies and supporting projects entering and through clinical development including translational activities. You will also generate and access large-scale data resources and build and drive collaborations with internal groups, CROs and academic partners to support GI²projects. Here, you will develop, evaluate, and apply state-of-the-art computational biology methods for translational research, including systems biology, pathway/network analysis, machine learning, GWAS, TWAS, PGS, single-cell and single-nucleus RNA-seq, etc. You will also integrate and analyze translational and clinical, internal and public ‘omics datasets, to generate and evaluate hypotheses for patient stratification, biomarker validation/identification, drug mechanism identification, and new disease indication selection efforts. As part of the GI and Inflammation Therapeutic Area Unit (GI² TAU) team, you will report to the Head, Early Clinical Development (ECD), GI, and work with GI² TAU organization.

How you will contribute:
  • Manage a team of C&SB scientists and leading cross-functional teams as well as cross-culture and cross-location collaborations to achieve project goals.
  • Lead strategic planning and execution of C&SB supporting clinical and translational goals.
  • Build and maintain strong collaborative relationships with various key partnering functions, e.g. GI Drug Discovery Unit (GI DDU), GI Therapeutic Area Unit (GI² TAU), Clinical Science, Clinical Biomarker, Quantitative Science, and other functions and teams.
  • Biological knowledge in one or more areas of inflammation, inflammatory bowel disease, or liver and gut fibrosis.
  • Build, lead and contribute to key partnerships with academic and industrial entities.
  • Identify, build, and use bioinformatic pipelines to QC, process, and analyze omics data types including genomics, transcriptomics, single cell sequencing, proteomics, metabolomics and more.
  • Create visualizations, and interpret high dimensional data, and deliver and explain results to cross-functional teams.
  • Work collaboratively with data scientists and data engineering groups to enhance our computational infrastructure, user interface, query, and visualization capabilities.

Minimum Requirements/Qualifications:
  • PhD degree in a scientific discipline, with 15+ years of working experience.
  • Previous industry leadership experience, with strong background in applying C&SB to research, translational and clinical programs.
  • Established leadership experience with people, project and portfolio management.
  • Excellent ability to manage and develop direct reports and teams to achieve computational biology support for discovery, translational and clinical projects.
  • Ability to drive and coordinate collaborations and influence project teams to use C&SB in study designs, and to extract maximum value in interpretation of results.
  • Excellent management, communication, and interpersonal skills, to ensure this leadership role of computational biology supports GI projects.

What Takeda can offer you:
  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

Base Salary Range: $198,100.00 to $283,000, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.



EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


USA - MA - Cambridge - Binney St

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Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

For more information, visit

Stock Symbol: TAK

Company info
650 East Kendall Street
United States

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