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Principal MES Engineer

Working from Home
Start date
Feb 24, 2024

Job Details

A career at Resilience is more than just a job – it’s an opportunity to change the future.

Resilience is a technology-focused biomanufacturing company that’s changing the way medicine is made. We’re building a sustainable network of high-tech, end-to-end manufacturing solutions to better withstand disruptive events, serve scientific discovery, and reach those in need.

For more information, please visit

Position Summary & Responsibilities

ThePrincipal Manufacturing Execution System (MES) Engineer within Digital will be the executor of the Resilience automation strategy across the Resilience manufacturing network, including greenfield capital projects and asset integration enhancement initiatives. This individual will drive the MES strategy and deployment across greenfield sites and existing manufacturing facilities. This includes leading the project management, specification, configuration, administration, and maintenance of MES platforms and applications. The Principal MES Engineer will also drive MES software development lifecycle (SDLC), MES integration with electronic resource planning (ERP) and other systems, and continuous improvement initiatives within the Digital group. The Principal MES Engineer will collaborate with peers across departments and/or cross-functional teams to ensure completion of projects.


  • Analyze, recommend, and implement MES projects and enhancements across the Resilience manufacturing network, with focus on manufacturing execution, automation techniques and equipment integration.
  • Design & Build of the MES platform, including implementing modifications to improve operational performance and product quality.
  • Manage multiple projects simultaneously to keep projects on track and timeline for completion.
  • Supports automation activities throughout technology transfer into the manufacturing network and provides continued support throughout manufacturing campaigns.
  • Develop, modify, and redline requirements/specifications related to integration of Manufacturing platforms (e.g. equipment, software, P&ID, network topology, PFD).
  • Collaborate closely with business stakeholders to prioritize projects/work and align digital project delivery to site operational schedules.
  • Coordinate with Digital Quality and Digital Systems Assurance to design and implement SDLC lifecycle documentation and validation protocols.
  • Build relationships and collaborate with Manufacturing, Technical Operations/Engineering, Manufacturing Science/Strategy & Technology, and Quality organizations.

Minimum Job Qualifications

  • In-depth knowledge of manufacturing technologies and systems at all levels of the ISA95 stack
  • Substantial project management and coordination experience associated with the execution of capital projects in an industrial environment is required.
  • Experience with MES (Manufacturing Execution System) integrations to SCADA, ERP, and other manufacturing critical systems.
  • Demonstrated ability to handle multiple competing priorities and projects in a fast-paced environment with a proven track record for delivering results on large, cross functional, global projects
  • Relevant experience in biomanufacturing
  • Hands-on experience with IT change management across domains (security, software, network, hardware, etc.)
  • Hands-on experience with computer systems validation and/or computer systems assurance
  • Fluid collaboration skills across business, IT, and external vendors/suppliers

Preferred Job Qualifications

  • 15+ years of experience in manufacturing operational technology (OT) environments
  • Bachelor of Science degree in an Engineering discipline. Preferred area of study:  Chemical, Biomedical/Bio, Electrical, or Mechanical Engineering.
  • Fluency in supporting the digitization of manufacturing & engineering business process by bringing the IT know-how to business partners in Manufacturing and Technical Operations.
  • Experience with the Cloud preferably AWS and key approaches to security and change management/deployment (infrastructure as code)
  • Builder mentality that seeks to produce innovation, agility, and velocity to support business-as-usual operations and new project implementation.


Resilience is an Equal Employment Opportunity Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, disability status, physical or mental disability, genetic information, or characteristic, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state, and local laws. Requests for reasonable accommodation can be made at any stage of the recruitment process.

Resilience offers employees a robust total rewards program including equity, an annual cash bonus program, a 401(k) plan with a generous company match and our benefits package which is thoughtfully designed to support our employees with great healthcare (including medical, dental and vision), family building benefits, life and disability insurance, flexible time off, paid holidays, other paid leaves of absence, tuition reimbursement and support for caregiving needs. Our target base pay hiring range for this position is $150,000.00 - $225,000.00 per year. Actual base pay is dependent upon a number of factors, including but not limited to, the candidate’s geographical location, relevant experience, qualifications, skills and knowledge. Excited about Resilience and the biomanufacturing revolution? We encourage you to apply and start a conversation with one of our recruiters.


Resilience is a technology-focused biomanufacturing company dedicated to broadening access to complex medicines. Founded in 2020, the company is building a sustainable network of high-tech, end-to-end manufacturing solutions to ensure the treatments of today and tomorrow can be made quickly, safely, and at scale. Resilience seeks to free its partners to focus on the discoveries that improve patients’ lives by continuously advancing the science of biopharmaceutical manufacturing and development. For more information, visit and follow us on Twitter @IncResilience 

Company info
9310 Athena Circles
La Jolla
United States

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