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2024 Summer Internship, Neuroscience

Employer
Arvinas Inc.
Location
New Haven, CT
Start date
Feb 23, 2024

View more

Discipline
Science/R&D, Neuroscience
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Pharm Country

Job Details

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs: ARV-766 and bavdegalutamide for the treatment of men with metastatic castration-resistant prostate cancer; and vepdegestrant (ARV-471) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. Arvinas, as part of its overall business strategy, selectively assesses opportunities for potential collaboration, license, marketing and royalty arrangements, and similar transactions, to advance and accelerate the development and enhance the commercial potential of its product candidates.

#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com

 

Position Summary 

The incumbent will be trained and mentored by Arvinas biology staff in the basic day-to-day processes that support preclinical drug discovery for neurology indications.  Through experiential learning, the selected candidate will become proficient in fundamental cellular and molecular biology techniques, the basic principles of pharmacology, data analysis, documentation, and interpretation.  Under the guidance of staff, the intern will implement basic scientific techniques at the bench, critically read, process, and present selected papers from the relevant scientific literature, and a summary of their work at an end-of-summer student colloquium.

This position reports to a Research Scientist and will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Learn selected basic biology techniques from Arvinas staff with the goal of proficiency to the point of independently following detailed protocols to support in vitro pharmacology.

Techniques Including:   

  • Cell culture, including CNS cell types.
  • Quantitative protein analysis of PROTAC-mediated degradation and functional endpoints using in vitro CNS disease models (Western, luminescence-based readouts, and/or capillary immunoassay)
  • Cellular target engagement (immunoprecipitation, BRET/FRET-based readouts)
  • Document experimental work in an Electronic Laboratory Notebook & learn associated ELN protocols
  • Attend project meetings and internal seminars at direction of Mentor
  • Read and present key papers from the relevant scientific literature at Summer Student Journal Club

Qualifications

  • Currently enrolled in an undergraduate degree program with a science discipline component
  • Prior lab-based biology background, including coursework with a lab component, a plus but not required
  • Prior independent research experience is a plus, but not required.

Education

  • Enrolled in college or graduate level course work to support B.S. or B.A. in relevant scientific discipline.

 

 

#LI-Remote

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer   

Company

At Arvinas, we’re leading the creation of an entirely new way to treat disease through therapies that target and degrade disease-related proteins. We are a clinical-stage biopharmaceutical company focused on developing new therapeutics for cancers and other difficult-to-treat diseases. Our proprietary PROTAC® protein degraders, or proteolysis-targeting chimeras, work by harnessing the body’s own natural protein disposal system to degrade and remove disease-causing proteins.

Our leading programs are focused on high-value targets in cancer, including the androgen and estrogen receptors associated with prostate and breast cancers, respectively. Our hope is to unlock the full potential of PROTAC protein degradation by developing our own robust pipeline and by partnering with the world’s leading drug development companies.

QUALITY BENEFITS
Designed with health and wellness in mind, employees and their families are eligible for:

  • Medical, dental, and vision options, including a generous company contribution into an HSA
  • Paid maternity and paternity leave
  • FSA, HSA, Healthcare, and Dependent Care accounts
  • Company provided life insurance and short/long-term disability coverage
  • Additional voluntary benefits including critical illness, hospital care and more

COMPENSATION & EQUITY
Central to our organization is attracting, retaining and engaging the best and brightest by sharing in the success of our organization:

  • Competitive salaries and an annual incentive program
  • 401K matching program with immediate vesting
  • Eligibility for long-term equity incentives upon hire and annually

TIME OFF
We believe it’s important to relax, unwind and enjoy life’s moments:

  • Paid vacation
  • A year-end office closure
  • Observed company holidays
  • Paid sabbatical upon 5 years’ tenure

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. We take our work very seriously, but we also ensure we’re having fun while doing it. We embrace the freedom to pursue innovation, think creatively, and give back. We care about each other, celebrate our accomplishments, and rise up to encourage our colleagues through challenges. If you think one of these open positions might be a fit, we’d love to hear from you.

Company info
Website
Location
5 Science Park
395 Winchester Ave
New Haven
Connecticut
06511
United States

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