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Sr. Associate Engineer, Polysaccharide Downstream Pilot Plant

Vaxcyte, Inc.
San Carlos, California
Start date
Feb 19, 2024

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Engineering, Chemical Engineer, Science/R&D, Chemistry
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay

Job Details

Company Profile:
Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte’s PCV franchise, consisting of VAX-24 and VAX-31, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.
Vaxcyte is looking for an energetic and talented Sr. Associate Engineer to contribute to the Polysaccharide Downstream Pilot Plant function within the CMC team. Vaxcyte is developing a multi-valent polysaccharide-based conjugate vaccine, based on a novel carrier protein produced using the Xpress CF platform. Polysaccharides are a critical component in conjugate vaccines.
The successful candidate will have practical laboratory experience related to biotechnology, biopharmaceuticals, or vaccine industries, particularly around purification of macromolecules.
The candidate will be eager to utilize and learn new laboratory skills as this person will be responsible for collaboration on experimental design and execution of experiments at pilot scale for scale down modelling efforts and manufacturing program development. This position will require >50% time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate will write detailed technical reports, present experimental results internally, and potentially interface with external CMO partners.
Essential Functions:
    • Perform downstream pilot scale experiments within DSP operations, focusing on the scale down model of the current manufacturing process, including all related set-up operations of buffer preps.
    • Operate and maintain instrumentation for polysaccharide purification including Akta chromatography skids, TFF system, depth filtration systems, and centrifuges.
    • Perform analysis and interpret results for polysaccharide and impurity assays (Anthrone, Lowry, SEC-MALS, HPAEC-PAD etc.).
    • Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic notebooks.
    • Authoring/development of experimental protocols prior to experiment execution and respective results and reports.
    • Present/communicate data to polysaccharide team.
    • Contribute to technical discussions within the polysaccharide team.
    • Works within a team environment and provides support as necessary to further the team’s initiatives.

    • Senior Associate Engineer: BS in Chemical Engineering, Biochemistry, or a related discipline, with 5+ years of industry experience; MS with 3+ years of industry experience.
    • Practical experience in supporting/execution of bioprocess operations such as Chromatography, TFF, depth filtration, and continuous centrifugation with a strong experience in 1 area.
    • Demonstrated understanding/proficiency with engineering principles involved in scaling processes and transferring processes (lab, pilot, manufacturing).
    • Experience in writing experimental protocols and summary reports.
    •    Benchling experience is a plus.
    • Familiarity with DoE (Design of Experiments) principles and ability to perform statistical data analysis with collected data.
    •    Process characterization experience is a plus.
    • Working knowledge of the requirements of GxP standards.
    • Demonstrated success working in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver results.
    • Strong interpersonal skills, with excellent written and verbal communication skills.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Associate Director, Polysaccharide Pilot Plant and Manufacturing
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $107,000 – $123,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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