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Senior Scientist I, Biologics Drug Product Development

Employer
AbbVie
Location
Irvine, California
Start date
Feb 18, 2024

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Job Details

Within the Biologics CMC Development organization, the Senior Scientist I will support the formulation development of protein biologics from early development through commercialization, with a specific focus on neurotoxins for therapeutics and aesthetic use. Key to this role is the ability to develop scientific strategies, navigate challenges, and oversee the work of matrixed resources. This is an exciting opportunity to join a dynamic and collaborative drug product development team to bring novel neurotoxins-based therapies and products to our patients.

Responsibilities

  • Develop preclinical and clinical formulations, including liquid and lyophilized dosage forms, and related drug product manufacturing processes.
  • Transfer drug product manufacturing process to internal and external fill-finish facilities and provide on-site support as needed.
  • Support development stability and clinical in-use studies to guide dose solution administration.
  • Generate high-quality data based on sound scientific principles and prepare formulation data summaries, technical reports, scientific presentations, and regulatory documents.
  • Participate in drug product development teams and contribute to the planning and execution of product development studies including formulation and drug product process development, based on project goals and timelines.
  • Actively interact with CMC members and other AbbVie stakeholders to enable the successful development of AbbVie drug products.
  • Drive innovation by investigating and developing novel experimental approaches and/or technologies in the field of drug product development and raise visibility within the scientific community through external presentations and publications.

  • Qualifications

    • Ph.D in Pharmaceutical Sciences, Chemical Engineering, Analytical Sciences, Biochemistry or equivalent field with 0-3 years of experience or BS/MS degree with 8-10 years of relevant experience in the biotechnology or pharmaceutical industry.
    • A strong technical background encompassing protein chemistry, analytical development, and formulation development is required.
    • Candidates with hands-on expertise in analytical techniques used for protein characterization and stability studies (e.g liquid chromatography (SEC, ion exchange, HIC), DSC, CD and Fluorescence spectroscopy, sub-visible particle characterization, DLS, Karl Fisher) will be preferred.
    • Technical expertise and practical experience in lyophilization process development of proteins as well as solid-state characterization are highly desirable. Prior experience in aseptic manufacturing process development, scale up, and technical transfer is a strong plus.
    • Preference to candidates with demonstrated experience in solving problems and driving innovation.
    • Excellent communication and written skills are required.

    *Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

    • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
    • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
    • This job is eligible to participate in our short-term incentive programs. 

    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

    #LI-Onsite

    AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    Company

    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    Website
    Phone
    1-800-255-5162
    Location
    1 North Waukegan Road
    North Chicago
    Illinois
    60064
    US

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