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Senior Biological Research Scientist I

Irvine, California
Start date
Feb 17, 2024

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Job Details


Envision working with energetic colleagues and inspirational leaders. Now, place yourself in that mix, leading discussions, asking the right questions, and driving results.  AbbVie is always striving to find top scientists to work at our Irvine, CA site


What your manager wants you to know:

“I’m looking for a team player with experience modeling disease through complex in vitro methods to join our Ophthalmology Research Discovery group.  If you want to be part of a team committed to tackling challenging scientific problems to discover new medicines for vision-threatening diseases and enjoy collaboration and critical thinking, I would be very interested in receiving your resume.  Let’s discuss what you can bring to the team and how the team might help you achieve your goals for the future.”

We are looking for a team player with experience in modeling disease through complex in vitro methods to join our Ophthalmology Research group.  The candidate will be part of a team committed to tackling challenging scientific problems to discover new medicines for vision-threatening diseases and enjoy collaboration and critical thinking.  The candidate will lead and contribute to implementing strategies for discovering and validating targets in ophthalmology. The candidate will participate in a team of scientists to lead various activities, including target identification/validation approaches and drug discovery using in vitro, in vivo, or multi-omics methodologies to evaluate pharmacology in collaboration with internal and external stakeholders/experts. The candidate will be a hands-on experimentalist capable of leading scientific projects. Emphasis is on performing hands-on work successfully, demonstrating scientific leadership skills, and interacting in a team environment. The candidate will assist in the development of in vitro models as well as plan and conduct in vitro cell-based assays to screen novel drugs.  Prior experience in cell-based screening assays, and complex in vitro models (iPSC-derived cells, co-culture, organoids) is an asset.  In addition, the candidate should have a strong track record of cross-functional collaborations along with excellent written and oral communication skills.


Be a trusted and expert scientific partner with experience and passion for the following:     

  • Research and understand relevant target/disease biology; design and implement experimentation to validate hypotheses.
  • Data analysis and interpretation
  • Active participation in program/project team meetings.
  • Provide critical technical evaluation of program research activities. Issue technical reports for internal distribution.
  • Prepare presentations and represent the group to cross-functional teams.
  • Maintain awareness of current developments in the field through comprehensive reading and analysis of the literature and attendance at appropriate scientific meetings

  • Qualifications 


  • Ph.D. education in a relevant biological discipline (e.g., pharmacology, neuroscience, ophthalmology, immunology, biochemistry) or MS with 5-7 years of relevant experience.
  • Experience in the fields of Glaucoma, Ophthalmology, Fibrosis or Neuroscience is desired
  • Experience with in vitro and in vivo functional assays and the application of these techniques to pharmacological studies required.
  • Experience in cell-based retinal ganglion cell (RGC) model, Lamina cribrosa (LC), or glial cells, is highly desired.
  • Experience in multi-omics study design and execution, such as SnRNA seq, ScRNA seq and spatial transcriptomics is preferred.
  • Experience in bioinformatic analysis, IPA or equivalent is highly desired
  • Strong scientific skills with the ability to collaborate with project team members.
  • Must have excellent written and oral communication skills
  • Committed to integrity, accountability, transparency, scientific rigor, and drive

    Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

    ·      The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

    ·      We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

    ·      This job is eligible to participate in our short-term incentive programs. 

    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

    AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    1 North Waukegan Road
    North Chicago

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