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Scientist II, Analytical Chemistry

South San Francisco, California
Start date
Feb 16, 2024

Job Details

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. 

AbbVie’s Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Scientist II to join a new team that will be responsible for process analytics. The Process Analytics team’s mission will be to provide enhanced understanding of cell line, upstream, and downstream processes, and to streamline process development decisions and timelines through application of data-rich, high-throughput, rapid-turnaround analytics and automation.  In this role, you will report to the lead of the Process Analytics team and be responsible for analytical testing and evaluation of process intermediates to enable cell line, cell culture, and purification development.  Additionally, you will be responsible for investigating, developing, and optimizing innovative, fit-for-purpose in-process methods that advance analytical capabilities to enable cell line and process development.   

Responsibilities include: 

Perform analytical testing of process intermediates using multi-attribute methods (MAM), LCMS peptide mapping, mass spectrometry, U/HPLC, capillary electrophoresis, and other methodologies and automation 

Collaborate closely with Cell Line Development and Process Development scientists to execute analytical testing for cell line development and process development experiments   

Investigate, develop and optimize innovative, data-rich, high-throughput, and automated in-process analytical methods and workflows to enable and enhance process understanding and process development efficiency 

Interpret and communicate in-process analytical results to collaborators and stakeholders in a manner that informs cell line selection and process development decisions 

Collaborate and communicate effectively with Analytical Molecule Leads to provide data and results from in-process testing for consideration in the context of the overall Analytical Development/QC control strategy 

Engage with analytical subject matter experts to investigate in-process findings that warrant further interrogation with advanced extended characterization methodologies  

Work efficiently, collaboratively, and cross-functionally toward project timelines and goals  

Document laboratory work according to good documentation practices 

This position is an onsite, lab-based role.  To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists. 


    BS/MS degree in analytical chemistry, chemistry, biochemistry, or related field.  BS with 7+ years or MS with 5+ years of relevant industry experience and strong record of technical achievement. 

    Proficient in LCMS peptide mapping for PTM analysis of antibodies, bispecifics, and similar protein therapeutics and mass spectrometry analysis of intact proteins 

    Hands on proficiency in analysis of antibodies, bispecifics, and/or ADCs with HPLC, UPLC, and/or CE 

    Experience with multi-attribute methods (MAM) and automation pertaining to liquid handling, sample preparation, testing and result reporting is a plus 

    Experience in applying liquid handling robots and automation for sample cleanup, sample preparation, and analysis is a plus 

    General understanding of CMC Analytical Development of protein therapeutics is desired 

    Experience in application of analytical methods to process development and general familiarity with process steps employed in manufacture of recombinant protein therapeutics is a plus 

    Understanding of therapeutic protein quality attributes, especially in the context of influence of cell line and manufacturing process on such attributes is desired 

    Ability to independently design, execute and interpret critical experiments to answer scientific questions 

    Ability to learn, understand and master new experimental techniques. 

    Must have strong verbal and written communication skills 

    Ability to author technical reports and presentations  

    Must be able to contribute to scientific/technical discussions 

    Must have ability to work collaboratively with a high degree of productivity in a dynamic, fast-paced, cross-functional environment 


    Travel: Up to 5% 

    Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

    The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

    We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

    This job is eligible to participate in our short-term incentive programs. 

    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

    AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    1 North Waukegan Road
    North Chicago

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