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Sr. Manager, Enterprise Systems

Vaxcyte, Inc.
San Carlos, California
Start date
Feb 15, 2024

Job Details

Company Profile:
Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte’s PCV franchise, consisting of VAX-24 and VAX-31, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.
The Senior Manager Enterprise Systems IT role serves as a program manager and techno-functional expert for Vaxcyte’s current and future enterprise applications and related technologies. Working closely with business and managed services partners, this role is responsible for helping implement, manage, and maintain Vaxcyte’s Enterprise Systems. While technical in nature, this role drives business value by blending technology expertise, program management and business process know-how. This is a hands-on role that reports to the Senior Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters.
Essential Functions:
    • Provide program management and technical oversight for ERP evaluation project.
    • Program management and technical oversight for implementation and support of iPaaS tool.
    • Establish and maintain close working relationships with Enterprise Systems business partners.
    • Create and maintain system-specific IT documentation such as operating procedures, templates, design standards and forms.
    • Manage SOX controls required for Enterprise Systems
    • Provide project management support for new initiatives and enhancement efforts.
    • Formalize and facilitate change intake and Change Review Board processes.
    • Oversee end-to-end change control activities for configuration changes and platform upgrades.
    • Support SOX or other audits when required.
    • Manage assigned Enterprise System related budget and procurement.
    • Support development of a multi-year Enterprise Systems technology investment roadmap.
    • Configure and customize supported Enterprise applications to meet business requirements.
    • Ensure data quality and accuracy by performing regular data audits and implementing data validation rules.
    • Triage, troubleshoot and help resolve issues related to Enterprise applications.
    • Work closely with stakeholders to understand business requirements and provide solutions using Enterprise applications.
    • Train users and provide ongoing support for various Enterprise Applications
    • Lead requirements gathering, analysis, design, and configuration activities.
    • Coordinate with managed services, business partners and assurance teams to implement planned releases and functional change requests.
    • Assist with end-user and business owner training, including creation of training materials.
    • Plan and conduct requisite periodic reviews and related compliance activities.
    • Work with IT Operations to support provisioning and de-provisioning efforts. 

    • Bachelor’s degree in computer science, information systems, or related field.
    • Multiple ERP systems implementation experience (preferably SAP or Oracle).
    • iPaaS tool implementation experience (e.g. Boomi, Workato, etc.).
    • 5+ years of experience with ERP systems.
    • 10+ years of total IT Systems experience.
    • 5+ years program management experience.
    • Biotechnology company experience.
    • As is/to be process mapping and analysis.
    • Solid problem-solving skills and ability to troubleshoot issues including root cause analysis.
    • Excellent communication skills and ability to work collaboratively with stakeholders.
    • Technical writing skills for updating SOPs, WI, Knowledgebase articles etc.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Senior Director, Enterprise IT Systems
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $188,000 – $202,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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