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Associate Scientist – Biology, Protein Biochemistry

Employer
Terray Therapeutics
Location
Monrovia, CA
Start date
Feb 14, 2024

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Discipline
Science/R&D, Biology, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Beach, Best Places to Work

Job Details

Company Overview

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data mapping interactions between small molecules and causes of disease that get increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Position Summary

Terray Therapeutics is seeking a motivated, creative, and experienced biochemist to join our biology team. The candidate will work closely with the protein scientist in the biology team and be a pivotal member in collaboration between our screening and assay development teams. Successful candidate will be expected to be familiar with basic physical properties of targets of interest (based on literature and experimental sources) and play a key role in protein engineering, initial assay development and optimization. This position offers a unique opportunity to be a part of a multidisciplinary team in the frontiers of drug discovery and development.

The core responsibilities of this job will be:

  1. Working closely with protein biochemist: Assess protein inventory, check the quality of our proteins in activity assays, characterize purity and post-translational modification using different techniques (Western Blot, SDS-PAGE, Size-Exclusion Chromatography, HPLC); optimize buffer and additive conditions for protein screening by thermal stability (nanoDSF, TSA).
  2. Occasionally, assist other departments in protein acquisition as well as perform protein direct labeling and production needs using SOPs.
  3. As needed, this role will be expected to work closely with other teams and provide assistance in assay optimization, development and sample preparation.
  4. Record experiments in electronic notebook, analyze data and communicate results.
  5. Support organization of lab and equipment as needed.
Experience and Qualifications

Part of Terray Therapeutics’ success is nurtured by a hands-on work environment where everyone is accountable, everyone is vested in a vision of excellence, and everyone actively takes part in the success of the business. Terray Therapeutics supports a positive work environment composed of engaged employees who feel appreciated, recognized, and free to be creative.

Qualifications include:
  • MSc with 3+ years or BSc with 7+ years of relevant industry experience in the field of biochemistry, enzymology or structural biology
  • Background in protein expression, purification and characterization using HPLC and AKTA/NGC is required
  • Hands-on experience with biochemical assays (enzymatic, FRET, BRET, assays) is preferred
  • Previous experience working with Liquid Handling systems (Tempest, BRAVO) in 96-well/384-well format is a plus
  • Previous experience acquiring binding data (Kd) using variety of methods (MST, ITC, SPR, GCI, etc.) is a plus
  • Excellent organizational, interpersonal and communication skills and can thrive in highly collaborative research environment
  • Demonstrated technical proficiency, attention to detail, ability to troubleshoot to solve problems and to deliver high quality data.

They will exhibit the ability to work well under pressure to provide results in a short timeframe. The company is looking for a highly responsive, goal-oriented individual who will bring significant energy and drive to solve complex technical problems and help us achieve our mission to advance human health.

Compensation Details

$80,000 - $120,000 (annually) depending on seniority; participation in the Company's option plan; 3% 401K contribution; full benefits

Company

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Company info
Website
Location
750 Royal Oaks, Suite 100
Monrovia
CA
91016
United States

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