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Executive Director / Vice President of Health Economics Outcomes Research (HEOR)

Annexon, Inc.
South San Francisco, CA
Start date
Feb 12, 2024

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Job Details

Work Location

Corporate Headquarters (South San Francisco, CA) – Hybrid

Will consider non-local candidates

Position Summary

Executive Director/ Vice President of Health Economics Outcomes Researcher (HEOR) is responsible for conducting research to assess the economic impact of healthcare interventions, with the goal of helping healthcare organizations make informed decisions regarding resource allocation and reimbursement.  As the leader of Health Economics Outcomes Research at Annexon, you will develop on-going professional relationships with healthcare decision makers, public and private payers and policy makers, as well as HEOR investigators. Will use various statistical and analytical methods to evaluate healthcare outcomes and costs and present your findings to internal and external stakeholders including healthcare providers, as well as hospital and managed care decision makers. This is an exceptional opportunity to contribute to the advancement of healthcare by providing evidence-based insights that can shape the future of patient care.


  • Support the HEOR strategy and plan for each program at Annexon, including design and execution of HEOR studies such as literature reviews, burden of illness analyses, budget impact models, patient-reported outcomes, and real-world evidence.
  • Ensure the generation of HEOR evidence addresses the needs and expectations of key stakeholders such as payers, health technology assessment agencies, health care providers, and patients
  • Collaborate cross-functionally with internal stakeholders including medical affairs, marketing, and clinical teams to ensure relevant health economics data is integrated into clinical studies and commercialization plans
  • Engage and collaborate with external partners including payers, health care providers, thought leaders, and decision-makers to establish and maintain strong relationships and partnerships and gather insights into research projects
  • Provide strategic guidance to internal teams on healthcare resource allocation and pricing strategies.
  • Present research findings to internal and external stakeholders in a clear and concise manner using appropriate communication channels.
  • Stay up to date with advancements in health economics methodologies and best practices. Identify and interface with regional and national HEOR & RWE experts and organizations, profile data sources and organizations who conduct real world outcomes research as they relate to Annexon’s products and therapeutic areas.
  • Add to the existing HEOR knowledge base of researchers, data sources and organizations who conduct real world outcomes research as they relate to Annexon’s products and therapeutic areas to support value messages.
  • Develop and communicate HEOR data of varying levels of complexity to formulary and healthcare policy decision-makers and their expert influencers in compliance with company policies. Increase the knowledge and awareness of the value propositions of Annexon’s potential future and marketed products allowing key healthcare and formulary professionals to make informed therapeutic decisions on behalf of patients and their providers.
  • Closely monitor national and regional changes in healthcare policy and payer environment, assess competitive data/gaps and communicate these back to the organization, to help Annexon stay competitive and on the cutting edge of EBM issues and HEOR data for purposes of strategic and commercial planning.


  • Prior Experience leading health economics, health outcomes, patient-reported outcomes, epidemiology, health policy, and related research methodologies in biotechnology or pharmaceutical industries.
  • Disease knowledge in rare diseases, neurology, ophthalmology, and/or immunology drug development highly desirable.
  • Minimum 15 – 20 years of relevant experience with an advanced degree in a related field (e.g PhD, DrPH, PharmD, MS)
  • Advanced written and interpersonal communication skills with an ability to present technical information clearly and simply.
  • Knowledge and experience in managed care and integrated delivery networks, formulary decision-making, and payment and access.
  • Skills to establish relationships with RWE experts in therapeutic areas of interest.


What Annexon offers

  • Diversity, Equity, Inclusion, and Belonging are important to us. We believe that diversity, equity, inclusion and belonging are essential for the strength of our business and the vitality of the communities we serve. We continuously work to build our pipeline of underrepresented candidates for our workforce, enhance, recruit and develop a best-in-class, diverse, equitable and inclusive workforce; ensure that Black, LatinX and other underrepresented candidates have long-term sustainable opportunities to work with Annexon; and hold our vendors to the same standards under which we operate. To learn more about Annexon’s diversity commitment, culture and values, please visit
  • A stimulating and rewarding workplace includes flexible work schedules, remote opportunities and the ability to achieve a work-life balance.
  • We are located in Brisbane, CA, with shuttle service from BART, CalTrain and the Ferry.
  • Annexon offers a competitive base salary and equity participation, employee stock purchase plan, as well as a comprehensive health benefit package that includes medical, dental, vision, 401(k), flexible spending plans, as well as other benefits


Company Summary

Annexon Biosciences is a clinical-stage biopharmaceutical company seeking to bring game-changing medicines to patients with classical complement-mediated diseases of the body, brain and eye. The classical complement cascade is a seminal pathway within the immune system that anchors and drives a host of autoimmune, neurodegenerative and ophthalmic diseases. Annexon is advancing a new class of complement medicines targeting the early classical cascade and all downstream pathway components that contribute to disease, while selectively preserving the beneficial immune functions of other complement pathways. Annexon is rigorously developing a pipeline of diversified product candidates across multiple mid- to late-stage clinical trials, with clinical data anticipated throughout 2023 and beyond.


EEO Employer – Annexon highly values Diversity, Equity, Inclusion and Belonging

Annexon Biosciences is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment based on race, color, religion, national origin, age, gender, sex, ancestry, citizenship status, mental or physical disability, genetic information, sexual orientation, veteran status, or military status. We are proud to promote a work environment where everyone, from any background, can do their best work.


Staffing Agencies

Annexon Biosciences does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with Annexon Biosciences. Please do not send agency CVs/resumes through Annexon’s website or Annexon Employees.  Inquiries must be sent to with the Subject Heading:  Staffing Agency Request.



We’re passionate about bringing game-changing therapies to patients suffering from serious complement-mediated autoimmune, neurodegenerative and ophthalmic disorders.

CSO, Larry Mattheakis, Ph.D
CFO, Jennifer Lew

Company Ownership: Public
Stock Symbol: ANNX
Stock Exchange: NASDAQ

Company info
1400 Sierra Point Parkway
Building C, 2nd Floor

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