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Sr. Director, Alliance Management

4D Molecular Therapeutics
Emeryville, California
Start date
Feb 10, 2024

Job Details

At 4D Molecular Therapeutics, Inc. (“4DMT”), we boldly innovate to unlock the full potential of genetic medicines for countless patients. We are committed to breaking boundaries and daring to cure as we develop new and foundational products and product components through our growing technology platforms.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.  

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators: 

•    Fully integrated clinical-phase company with internal manufacturing
•    Demonstrated ability to move rapidly from idea to IND
•    Five candidate products in the clinic and two declared pre-clinical programs
•    Robust technology and IP foundation, including our TVE and manufacturing platforms
•    Initial product safety and efficacy data substantiates the value of our platforms
•    Opportunities to expand to other indications and modalities within genetic medicine


The Sr. Director, Alliance Management will facilitate a collaborative and productive working environment with our industry partners, ensuring our teams operate according to best practices and within contractual terms. This internal and external-facing role requires excellent communication, people skills, and influencing management skills. The Sr. Director, Alliance Management will interact closely with the Executive Team and various functional leaders interfacing with our partners to ensure the success of our collaborations (including Research, Clinical, Medical Affairs, CMC, Finance, Legal and others).


  • Support Alliance Management team and diverse portfolio of partnerships and collaborations.
  • Ensure productive, collaborative alliances that operate consistent with contractual terms.
  • Act as a resource for the Executive Committee on alliance matters
  • Develop and maintain key relationships. Become a positive influencer internally and externally in support of alliance objectives
  • Partner with PTLs and PMs to align on a strategic position, prioritization changes, and areas of opportunity for improvement; Escalate issues to internal and external Sr. Leaders, as appropriate.
  • Proactively identify challenges within the alliance portfolio and work with internal and external stakeholders to define and implement solutions and risk mitigation plans.
  • Ensure effective communication between alliance partners. Assist in the provision of clear documentation in joint forums. Establish credibility, trust, and respect with partner organizations.
  • Establish a firm understanding of partner contracts. As alliances evolve and in collaboration with internal stakeholders, negotiate new terms and agreements (amendments, new or restated contracts) with existing partners.
  • Ensure consistent governance across all alliances enabling and supporting Joint Committee Meetings and other partnership meetings. Serve as the main point of contact for escalation of cross-company, cross-functional, and business conflicts (internal and external) which impact the collaboration.
  • Conflict/crisis management – proactively identify and resolve conflicts as needed or escalate to senior mgmt. for timely resolution.
  • Establish, improve, coach, and provide guidance to cross-functional team members to drive effective collaboration best practices to reflect a positive company reputation that supports partnering and/or fundraising efforts.
  • Partner with Business Development to ensure deal terms enable effective governance for new collaborations and partnerships. Actively contribute to Business Development projects (new partnerships) through review and input on term sheets and contract drafts.
  • Responsibilities may require a flexible work schedule outside of standard business hours due to partner time zone differences.



  • Advanced degree (Masters, Doctorate, or Bachelor’s degree)
  • Advanced degree in Life Sciences, Business, Law or related field preferred.


  • 8+ years bio/pharma, life sciences or related industry experience
  • 3+ years are in Alliance Management or external partner relationship management role; or equivalent combination of education, training, and experience.
  • Gene Therapy experience preferred


  • Strong knowledge and interpretation of contracts.
  • Solid negotiation skills with good command of complex, detailed matters.
  • Strong issue and conflict management skills with demonstrated experience in driving to resolution.
  • Broad understanding of global biotech/pharma industries with a strong understanding of drug discovery and drug development processes
  • Professional and has Executive presence; ability to work credibly and reliably with senior company executives, internally and with external partners; manages complex issues and communicates difficult matters; decisive but diplomatic.
  • Outstanding interpersonal and communications skills with a “roll up your sleeves” mentality; a team player who collaborates, oversees, coaches, and drives to meaningful outcomes and positive business impact
  • Actively listens and demonstrates emotional intelligence.
  • Strong project management and organizational skills.
  • Learning agility; ability to quickly grasp new or unforeseen situations, concepts and processes.
  • Self-motivated, requires minimal supervision and strong people management.
  • Familiarity with alliance management best practices, industry standards and collaborations.


Base salary compensation range: 

Bay Area Range: $230,000/yr - $275,000/yr

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.


4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.   Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities


4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.

At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.

While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.

At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.

4D Purpose Statement:  Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients



  • Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
  • Break Boundaries - Question the status quo and innovate beyond conventional approaches
  • Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
  • Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans

We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development. 

Company info
5858 Horton St. Suite 455
United States

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