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Senior Scientist II, Oncology Bioinformatics

Employer
AbbVie
Location
South San Francisco, California
Start date
Feb 10, 2024

Job Details

The Genomic Research Center Computational Oncology group (GRC-CO) at AbbVie is seeking a highly motivated computational biologist to play an integral role in a multi-disciplinary team focused on developing new therapies and approaches for cancer treatment. AbbVie’s GRC is a center of excellence for bioinformatics, functional genomics, human genetics and pharmacogenomics. The GRC works across all R&D including discovery and clinical development, and multiple areas such as process sciences, global epidemiology, search and evaluation, and corporate strategy.

This position is based at AbbVie’s brand-new CA headquarters located in South San Francisco, CA.  The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment to advance potentially curative therapies into the clinic by collaborating with development teams on novel immuno-oncology assets and by pioneering new perspectives of cancer through analysis of large-scale human cancer datasets. They will be responsible for working with project teams as a bioinformatics colleague, facilitating preclinical experimental design and interpretation, interrogation of large-scale data for mechanistic and biomarker insights, coordinating research activities across multiple team members, and formulating a data-driven foundation for patient and indication prioritization in the clinic. The successful candidate will be responsible for driving novel research into patient subpopulations, novel target discovery, and/or clinical features of oncology treatment.  They will also play a critical role supporting the development of the next generation of oncology therapies, specifically programs involved in the AbbVie-Calico collaboration

 

KEY RESPONSIBILITIES:  

  • Work with diverse project teams to analyze preclinical and clinical data to inform program development; identify program critical questions and help design solutions.
  • Interrogate large scale multiplatform ‘omics data to define relationships between cancer immune ecosystems and patient survival. Identify targetable subpopulations, combination opportunities, and/or novel targets for subsequent development.
  • Coordinate research activities within the AbbVie computational IO team and our computational colleagues across the AbbVie-Calico collaboration. Lead a small team in support of oncology program research; plan research activities, delegate appropriately, and manage effectively.
  • Bring together disparate data types in compelling visualization packages that provide colleagues with the ability to see both the overall landscape and granular details leading to improved decision-making.
  • Collaborate effectively across disciplinary and company boundaries as a member of the AbbVie-Calico collaboration. Capitalize on the unique strengths of both organizations to provide data-driven insights into immuno-oncology drug development.

  • Qualifications:

  • PhD. Degree in bioinformatics, statistics, computational biology, genomics or a related field; Master’s degree with typically 8 years of experience; Bachelor’s degree with typically 10 years of experience
  • Expertise in at least one general purpose programming/data science languages including but not limited to R, Python, Julia.
  • Expertise with common NGS data processing tools and statistical analysis.
  • Experience in cancer genomics.
  • Strong communication skills to foster collaboration in cross-functional teams
  •  

    Preferred:

    ·       In-depth understanding of technologies related to high-throughput experimental techniques, such as next generation sequencing technologies, single cell platforms, proteomics, microarray platforms, and their applications.

    ·       Familiarity with the development of visualizations and interactive figures communicating complex genomic and clinical data.

    ·       Operational and/or developmental familiarity with containers for deploying standard pipelines (Docker, AWS Container, Singularity, etc.)

    ·       Experience with oncology in both the preclinical and clinical stage are highly valued.

    ·       Familiarity with immuno-oncology concepts, the research space, and treatment landscape.

    ·       A collaborative and self-motivated individual with a strong work ethic, ability to work in a dynamic environment and able to manage multiple objectives in parallel and adapt to changing priorities.

    ·       Experience as a team lead, prioritizing research activities and delegating appropriately, is also highly prioritized.    

     

     

    AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


    Company

    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    Website
    Phone
    1-800-255-5162
    Location
    1 North Waukegan Road
    North Chicago
    Illinois
    60064
    US

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