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Research Associate - DMPK DICE

Eli Lilly and Company
San Francisco, California
Start date
Feb 5, 2024

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Regulatory, Science/R&D, Research, Pharmacokinetics
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At DICE Therapeutics (a wholly owned subsidiary of Eli Lilly and Co), we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms.

We seek an exceptional full-time lab-based Research Associate to join our Drug Metabolism and Pharmacokinetics (DMPK) team. This individual will be a key contributor to performing standard ADME/DMPK assays, such as microsomal stability, plasma protein binding, and metabolite identification. The individual will also be responsible for operating LC-MS instruments (QQQ and HRMS) with minimal direction.

Do you have experience in mass spectrometry while doing enzyme related work? This role may be perfect for you! Read on for more.

Key Responsibilities:
  • Perform ADME/DMPK assays such as microsome stability, plasma protein binding, reaction phenotyping, metabolite identification, etc. across drug discovery and development programs.
  • Develop, qualify, and/or validate methods on LC-MS/MS, Orbitrap HRMS, and other analytical platforms.
  • Analyze in vitro and in vivo samples for drugs and metabolites for applications in pharmacokinetics, toxicokinetics, biomarker, etc. studies.
  • Prepare and present weekly DMPK updates and provide written procedures and reports.
  • Collaborate with colleagues in Synthetic Chemistry, CMC, Clinical Pharmacology, and other relevant divisions within the company.
Minimum Qualifications:
  • BS or MS in chemistry
  • 0-6 years industry experience
  • Focus on analytical chemistry or biochemistry
  • Academic and/or industry experience with ADME, DMPK, and/or Pharmacology
  • Experience with chromatography techniques – HPLC, UPLC, etc.
  • Experience in applications of mass spectrometry in bioanalysis. Hands-on experience with high resolution mass spectrometry (HRMS) and/or quantitative LC-MS/MS (e.g., multiple reaction monitoring or MRM assays)
  • Experience with handling biological samples such as plasma, tissues, etc. for applications in bioanalytical assays

Lilly currently anticipates that the base salary for this position could range from between $77,000 to $175,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).  Of course, the compensation described above is subject to change and could be higher or lower than the range described above.  Further, Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. 

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.



Science has been our calling from the beginning. Colonel Eli Lilly founded the company in 1876 and charged employees to “take what you find here and make it better and better.” More than 147 years later, we remain committed to his vision through every aspect of our business and the people we serve, starting with discovering the best treatments for those who take our medicines and extending to health care professionals, employees and the communities in which we live. Moreover, you can also count on the team at Lilly to be incredibly civic-minded, supporting our communities through philanthropy, volunteerism, and a creative and innovative can-do spirit. 

Company info
893 S Delaware St
United States

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