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Translational PK/PD Modeler

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, New York
Start date
Feb 3, 2024

Job Details

We are seeking a highly motivated Associate Director of Translational/Preclinical Modeling that develops and implements quantitative and mechanistic PK/PD models to aid in the understanding of target biology, therapeutic modality selection/optimization, and contributes to early clinical trial dose selection and/or design, and to the advancement and strategic direction of modeling and simulation sciences.

This role is hybrid onsite - based in Tarrytown, NY.

A typical day in this role looks like:
  • Independently develops and implements quantitative and mechanistic mathematical PK/PD models that inform preclinical-to-early clinical translation, including human efficacious dose predictions and first-in-human dose selection.

  • Actively contributes to the advancement and strategic direction of modeling and simulation sciences.

  • Provides expert support to preclinical PK/PD project representatives and R&D project teams to design, complete and interpret in vitro and in vivo quantitative pharmacology studies. This included working with the Research PK group to optimize use of mouse PK data to inform translation to nonhuman primate and human PK.

  • Effectively integrates and summarizes modeling and simulation analyses into useable information for multidisciplinary project teams.

  • Remains apprised of emerging science and literature, and effectively collaborates with subject matter experts in Clinical Pharmacology, Quantitative Pharmacology and R&D to advance modeling and simulation sciences.

  • Shares findings and develops standard processes across disease areas and therapeutic approaches.

  • Committed to sharing technical expertise and the development / mentoring of others.

  • Presents work at internal/external scientific meetings and publishes work in scientific journals.

This role may be for you if you:
  • Are highly proficient in using one or more modeling and simulation platforms (e.g., Phoenix NLME, NONMEN, ADAPT, MATLAB, SimBiology, etc.)
  • Have a strong theoretical and practical foundation in pharmacokinetics, including non-compartmental, compartmental, PK/PD and PBPK.
  • Can effectively works in a fast-paced, highly-matrixed team-based environment and leverages scientific reasoning to influence key collaborators.
  • Have a track-record of learning (ie, publications) in new areas of biological sciences to develop quantitative and mechanistic PK/PD models for emerging therapeutic modalities.
  • Have familiarity with biotherapeutic modalities, including monoclonal and bispecific antibodies, gene therapy, CAR-T, siRNAs and other targeting agents preferred.
  • A proven track record of applying quantitative and mechanism-based PK/PD modeling and simulation approaches to advance the discovery and development of therapeutics.
  • Have experience developing and applying mechanism-based PK/PD models to guide R&D teams from early discovery to IND-stage clinical development.

In order to be considered qualified for this role, a minimum of a PhD + 6 years relevant industry experience. Degrees in Pharmacokinetics, Pharmaceutical Sciences, Engineering, Applied Mathematics or related fields are acceptable.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$148,100.00 - $241,700.00

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Company info
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States

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