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Research Associate - Marson lab

Employer
Gladstone Institutes
Location
San Francisco, CA
Start date
Jan 26, 2024

View more

Discipline
Regulatory, Science/R&D, Research, Laboratory
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

Category:Science
Lab/Area:Marson Lab

Description:

The Gladstone-UCSF Institute of Genomic Immunology is recruiting a Research Associate (RA) to help perform in vivo experiments in mouse models of immunotherapies and assist with the management of the mouse colony used for ongoing multidisciplinary cellular engineering projects. Our institute has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells. These new technical abilities have furthered our research into the genetic control of T cell biology as well as opened the door to novel cancer immunotherapies based on engineered human immune cells.

Key responsibilities

The RA will assist with the management and maintenance of institute mouse colonies located at Gladstone and UCSF. They will be trained in experimental procedures involving mouse models of cancer and autoimmune disease and participate in rigorous assessments of the in vivo efficacy of T cell therapies in these models. Tasks require routine handling of mice.

  • Perform routine mouse colony management duties (ear punching/ear tagging/tailing for genotyping, weaning, aging and sexing of pups, and euthanasia, et al)

  • Identify and implement required care for mice with health issues and mice on special treatment (special diet, fasting, treated water).

  • Maintain mouse database using Google sheets or mouse colony software.

  • Primer design and PCR troubleshooting

  • Perform PCR followed by electrophoresis or Sanger sequencing for genotyping

  • Place genotyping orders in TransnetYX and interpret the genotyping results

  • Collect blood samples via submandibular bleeding for downstream analysis

  • Learn and become proficient with techniques related to cancer models, such as intravenous injections of cancer cell lines and/or immune cells by tail vein injection or retro-orbital injection

  • Administer medication/reagents orally and via subQ, IP, IM, or IV

  • Assist with in vivo imaging in cancer models (bioluminescence)

  • Assist with cell culture and preparation for subQ injections or IV injections

  • Assist with dissection of spleen, lymph nodes, engrafted tumor for downstream analysis

  • Work collaboratively across a dynamic scientific environment

  • Maintain and ensure safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols.

  • Other related duties as assigned

Required Qualifications:

  • BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience

  • New graduates with a commitment to learning are welcome to apply

  • Must be able to work with mouse colonies

  • Experience with general laboratory techniques, especially basic molecular and cellular biology techniques (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis, DNA assembly, bacterial transformation, mammalian cell culture, etc.)

  • Excellent attention to detail, organizational and interpersonal communication skills (verbal and written)

  • Willingness and ability to learn new methods and skills for changing research priorities

  • Ability to work independently and as a member of a research team

  • Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines

  • Ability to comply with policies and procedures

  • Some evening and weekend hours are required

Preferred Qualifications

  • Prior experience with mammalian cell culture, especially T cell culture

  • Prior experience with DNA sequencing technologies, including Sanger and NGS

The Gladstone-UCSF Institute of Genomic Immunology is committed to improving diversity, equity, and inclusion in the genomic immunology field, from trainees to faculty, and is an equal opportunity employer.

Hiring Range:

$25/hr-$29/hr


Additional Information:
  • Title and salary will be commensurate with education and experience.
  • Gladstone is an equal opportunity employer.

Company

Gladstone is an independent, nonprofit life science research organization located in the epicenter of biomedical and technological innovation in the San Francisco Bay Area. Gladstone has created a research model that disrupts how science is done, funds big ideas, and attracts the brightest minds. Gladstone Institutes leads the way for innovative research in the biomedical field. We always seek dedicated and talented individuals to join our team.

Scientists know that using a diversity of approaches is often the most efficient strategy for solving a problem. New and different perspectives engender the very innovation that Gladstone prizes. This is one of the many reasons why we value diversity at Gladstone—be that a diversity of race, culture, religion, mental or physical ability, heritage, age, gender, sexual orientation or other characteristics. Our employees hail from more than 30 countries around the globe and we seek to hire the best and brightest for our diverse team of scientists and administrators. Career opportunities are available in both our administrative offices and our research areas.

Our Benefits
Gladstone offers eligible employees—and their dependents—a comprehensive range of benefits, including health insurance, retirement savings, and professional development.

Highlights

  • Health and Retirement
    • A choice of medical plans, flexible spending account, and retirement account options that include employer contributions help you take care of your health and your future.
  • Time Away from Work
    • More than just vacation days, our paid and unpaid leave policies offer flexibility to help you confront different stages of life including maternity and paternity leave, as well as other types of family leave.
  • Professional Development
    • Gladstone encourages employees to seek the skills they need to remain at the forefront of their profession. By supporting professional development workshops and continuing education, Gladstone provides employees with the resources they need to evolve in their role and in their career.
  • Gladstone Cares
    • A specially selected suite of benefits to support you in and out of the workplace. Includes resources for dealing with the many stages of life to specific coverage for family planning, and back-up child or elder care coverage.
Company info
Website
Location
1650 Owens Street
San Francisco
California
94158
US

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