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Principal Scientist - Bioinformatics (Clinical Development)

Gilead Sciences, Inc.
Foster City, CA
Start date
Dec 6, 2023

Job Details

Principal Scientist - Bioinformatics (Clinical Development)
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.
Job Description

Principal Scientist I, Bioinformatics

Position Overview:

Clinical Bioinformatics & Exploratory Analytics, as a part of the Clinical Data Science organization, supports drug development and other business use cases across Gilead by providing data analytical, engineering, and visualization solutions to enable scientific and other business exploration and decision-making, including statistical analysis, genomic data processing and analysis, general machine learning and deep learning, and other technical infrastructure. You will lead design, development, and implementation of statistical, bioinformatics and machine learning methods that integrate large multi-modal datasets to derive quantitative biological insights or perform hypothesis-driven biomarker analyses that support clinical development, translation of clinical findings, and other business decision-making. You will also contribute to presentations and publications of clinical genomics and biomarker findings either as conference publications, journal publications, or regulatory documents for new drug applications/filings submitted to regulatory agencies. The title and job scope may be adjusted based on the experience level.

  • Contributes to short- and long-range Clinical Bioinformatics & Exploratory Analytics strategies, plans and infrastructure development.
  • Plays a key role in both internal and external collaborations in complex data analysis, including but not limited to genomic data, protein assay data, cytokine and chemokine data from patient samples, to support patient stratification and biomarker selection for Gilead's clinical development programs.
  • Develops predictive models using statistical techniques and machine learning for analysis of large omics and high dimensional data from internal, publicly available, commercial and Real-World datasets to enable target assessment, drug combinations, understanding of MOA, disease mechanisms and resistance, etc.
  • Designs and executes data analysis plans, communicates findings and recommends follow-up actions in multiple settings, including one-to-ones, seminars, group and project meetings.
  • Plays a lead role in development of team and department-level standards, tools and templates.
  • Provides matrix leadership to multiple teams in the development and maintenance of bioinformatics processes and applications.
  • Develops and implements quality assessments, statistical analysis and data visualization for multi-omics datasets, e.g., RNA-Seq, single cell sequencing, WES, WGS, etc.
  • Provides expertise and technical consultation for external collaborations/partnerships in academia and industry.
  • Creates and manages resource plans for assigned work. Identifies cross-project synergies to leverage efficiencies and ensure consistencies where appropriate.
  • Ensures assigned work complies with established practices, policies and processes and any regulatory or other requirements.

Minimum Education & Experience:
  • PhD in bioinformatics, computer science, computational biology, genomics, statistics, data science, or a related field with 8+ years of bioinformatics or related experience
  • Extensive experience in cancer genomics/immunology and Biomarker/Bioinformatics experience in clinical development
  • Strong programming skills in key languages used by bioinformatics, data science, and statistics, e.g. R, Python, etc with proven capabilities to manipulate large and sophisticated data sets
  • Significant experience working with cloud computing systems, data management systems, advanced statistical software, and visualization tools.
  • Strong proficiencies in problem-solving, bioinformatics or other data analytics algorithm design, genomic and proteomic technologies, and high throughput experimental techniques, e.g., next generation sequencing technologies, single cell technologies and/or their applications.
  • Strong publication record in peer-reviewed journals
  • Outstanding presentation and communication skills that foster collaboration and teamwork

Knowledge & Other Requirements
  • Demonstrated ability to be a fast learner.
  • Demonstrated ability to be flexible and adaptable to change, to move between projects easily and provide support/expertise where needed.
  • Proven analytical abilities with high attention-to-detail as demonstrated through past experiences and/or academic achievements, including statistical knowledge, such as probability theory, statistical power, univariate and/or multivariate analysis, unsupervised and supervised analysis, regression analysis, survival analysis, etc.
  • Proven ability to conduct effective and efficient exploratory analysis on large volumes of data and identify key descriptive and inferential properties.
  • Strong communication and organizational skills. Demonstrable abilities to effectively communicate project direction and status to varying organizational levels, including leadership teams, executives, and steering committees.
  • Demonstrated excellence in complex project management and effectively managing multiple projects and priorities.
  • Line management (direct reports) experience with hiring, managing, and developing diverse top talent preferred.
  • Strong leadership presence with demonstrated ability to lead without authority and influence programs, projects and/or initiatives.
  • When needed, ability to travel.

The salary range for this position is: $214,795.00 - $277,970.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.



Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.



Gilead Sciences is a biopharmaceutical company that discovers, develops, and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide. Headquartered in Foster City, California, Gilead has operations in North America, Europe and Australia.

Company info
333 Lakeside Drive
Foster City
United States

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