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Scientist 1, Computational Biologist

Employer
BioMarin Pharmaceutical Inc.
Location
Working from Home
Start date
Dec 5, 2023

View more

Discipline
Science/R&D, Biology, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

Who We Are

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.


BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. Come join our team and make a meaningful impact on patients’ lives.

Genetics and Genomics are one of the key pillars on all BioMarin programs. The Genomics team within Research & Early Development (RED) is a key partner on BioMarin therapeutic programs at all stages of the pipeline.  We are seeking a Scientist 1 or 2 to join the discovery omics team to support early drug discovery and research efforts at BioMarin.

The successful candidate will have the opportunity to contribute to or lead diverse efforts such as identification of regulatory and potentially disease-modifying targets as well as molecular characterization of human disease and disease models. This is an opportunity to work with dynamic, cross-functional teams where you can apply your expertise in bioinformatics and satisfy your curiosity in human biology and molecular mechanisms. You can get directly involved in the discovery and development of the next generation of therapeutics (e.g., gene therapy and oligonucleotides), and collaborate with experts across a wide range of disease domains (neuro, cardiovascular, musculoskeletal, non-oncology hematology). Most importantly, you will have a chance for your work to have immediate impact on a fast-moving drug discovery and development process, to improve the lives of patients.

Responsibilities:
  • Analyze and integrate omics data to drive disease understanding, disease model characterization, target identification, and molecular characterization.
  • Develop and apply methods to identify new regulatory mechanisms, particularly at the RNA level, which we can target to treat genetic diseases.
  • Communicate discoveries to internal colleagues with a variety of backgrounds and to the wider scientific community through presentations and publications.
  • Collaborate to empower colleagues in Functional Genomics, Clinical Genomics, and Statistical Genetics, and our partners in the therapeutic areas.
  • Evaluate and develop bioinformatics methods to analyze and integrate omics data and report results. Examples include RNA-seq, single cell RNA-seq, long read RNA-seq and CUT&RUN data.



Qualifications

  • PhD in computational biology, bioinformatics, biology, or related fields.
  • Hands-on experience to manage, analyze and interpret large omics datasets, particularly transcriptomics data.
  • Strong computational abilities and fluency in at least one major programming language (ideally Python or R).
  • Desired: Background in molecular biology, particularly RNA biology, or a strong interest in these fields.

Level Requirements:

Scientist 1:

  • PhD or equivalent relevant experience, plus 0-2+ years industry experience

Scientist 2:

  • PhD or equivalent relevant experience plus 2-5+ years industry experience

Workstyle:
            
            Hybrid requires an onsite presence 2x weekly at our San Rafael, CA location. (zip 94901)
            Role is virtual if you live 100+ miles from our San Rafael, CA location. (zip 94901)


We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Company

BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.

Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.

Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.

Company info
Website
Location
California
United States

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