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Principal Scientist/Team Leader in Antibody Discovery

Bristol Myers Squibb Company
Redwood City, California
Start date
Dec 1, 2023

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Science/R&D, Biotechnology
Required Education
Masters Degree/MBA
Position Type
Full time
Biotech Bay, Best Places to Work

Job Details

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Here, youll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. Youll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We are looking for a highly motivated scientist to lead the B-cell and NGS focused Antibody Discovery team within the Antibody Generation group. The ideal candidate is an experienced scientist with a deep understanding and hands-on experience in antibody generation and sequence repertoire analysis for developing innovative therapeutics. This is an exciting opportunity to make a significant impact within a department that is driving the biologics therapeutics pipelines in BMS. In this role, the candidate is expected to develop and utilize multiple technologies including Single B-cell Cloning, Display, and Next Generation Sequencing to generate, characterize, and deliver sequence diversified and high-quality antibody lead candidates. The candidate will also be expected to closely collaborate with computational scientists and biology project leads to progress the BMS biologics portfolio.

Major responsibilities:
  • Lead a team of 4-5 employees within Antibody Generation
  • Deliver therapeutic lead antibody candidates that meet the project progression criteria
  • Optimize the existing Single B Cell and NGS platforms towards a high performing, robust lead delivery platform with seamless connection to downstream groups. Collaborate with Automation to increase efficiency and match future demand.
  • Drive innovation in binder discovery from immune and synthetic repertoires to capture functional diversified leads
  • Serve as Discovery Biotherapeutics representative to advance programs from idea to lead candidate selection
  • Drive the science and contribute to the vision in the technology development space especially in machine learning driven antibody discovery and gene capture.
  • Present program updates and data at meetings.
  • Contribute to patents, publications, conference presentations, and technical reports for regulatory submissions.
  • Accomplish goals under project team timelines

Basic Qualifications:
  • Bachelor's Degree in molecular biology or immunology with 8+ years of academic / industry experience
  • or Master's Degree in molecular biology or immunology with 6+ years of academic / industry experience
  • or PhD in molecular biology or immunology with 4+ years of academic / industry experience

Preferred Qualifications:

  • Immunology with 4 years of industry experience or other relevant experience.
  • High proficiency in all critical molecular biology techniques with focus on high throughput, high sensitivity gene rescue from single cells and immune tissues
  • Experience with antibody V gene capture, NGS sequencing and analysis of large sequence repertoires for smart lead selection
  • Hands-on experience in display technologies such as yeast or phage display is a plus
  • Experience with leading a team is required.
  • In-depth knowledge of B/T cell biology and humoral and cell mediated immune responses.
  • Highly innovative and self-motivated.
  • Excellent time management and organizational skills.
  • Demonstrated ability to work in a highly matrixed collaborative environment

The starting compensation for this job is a range from $121,000 to $167,200 plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.


Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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430 E. 29th St
14th Floor
New York
New York
United States

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