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Bioinformatics Analyst II/III

Frederick National Laboratory for Cancer Research
Bethesda, MD
Start date
Dec 1, 2023

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Information Technology, Bioinformatics, Science/R&D
Required Education
Bachelors Degree
Position Type
Full time

Job Details

Bioinformatics Analyst II/III

Job ID: req3692
Employee Type: exempt full-time
Division: Bioinformatics and Computational Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.


The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.

 The Bioinformatics and Computational Science (BACS) Directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of bioinformatics and computational science by developing and applying world-leading computing technologies to basic and applied biomedical research challenges, data science, supporting critical operations, developing and delivering national data resources, and utilizing leading-edge software.

The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS and serves as a hub of translational scientists with expertise in machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, protein modeling, bioinformatic analysis of omics data, and other applications of computational and data science. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research.

 NCI’s Pediatric Oncology Branch is dedicated to improving outcomes for children and young adults with cancer and genetic tumor predisposition syndromes, through translational research that spans basic science to clinical trials. Within NCI’s Pediatric Oncology Branch (POB), the Tumor Evolution and Genomics Section (TEGS) encompasses a laboratory program that intends to model and understand tumor evolution and progression in hopes of enlightening potential areas of therapeutic intervention. Specifically, the group studies pediatric soft tissue sarcomas which are a diverse group of tumors with distinct histologic and genetic features. This diversity makes cohesive study of any sub-group of tumors a daunting undertaking, requiring both a focused laboratory and clinical infrastructure. The group employs a bedside-to-bench-to-bedside, collaborative, technology-driven approach coupled with novel model systems and patient clinical samples to leverage the strengths of the Intramural Research Program (IRP) and the clinical program of the POB. The TEGS harnesses emerging methodology and applies unique technologies in hopes of accelerating therapeutically relevant discoveries. Currently, the group is actively applying a variety of innovative single cell solution sequencing approaches, spatial transcriptomic platforms, and novel genetic screening strategies to trace survival characteristics of therapeutically resistant cells. 

  • Provide competent bioinformatics support for the analysis, interpretation, and visualization of next-generation sequencing (NGS) data and other Omics applications (eg. Bulk & scRNASeq, long read sequencing, WGS/WES sequencing, DNA methylation etc.)
  • Provide expert hands-on analysis support for integration and interpretation of multi-modal NGS datasets
  • Benchmark and implement novel open-source algorithms/tools for assessing intra- and inter-tumoral heterogeneity
  • Analyse and visualize spatially resolved RNA sequencing and imaging data from multiple platforms
  • Interact with collaborators on project goals, facilitate experimental design, and suggest bioinformatics solutions for biological and translational questions
  • Automate bioinformatics pipelines incorporating existing open-source tools and custom algorithms
  • Manage active and archival storage; submit datasets to public databases/repositories
  • Prepare analysis summaries/reports and version control scripts and pipelines on GitHub
  • Contribute to establishing tumor atlases for pediatric rare tumors
  • Provide technical support and training to TEGS/POB PIs and staff, including access to public databases and web-based tools
  • Work closely with researchers and analysts at both TEGS/POB and ABCS and contribute to the complete life cycles of bioinformatics projects
  • Other duties as required

Candidates with these desired skills will be given preferential consideration:  

  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S..
    • Bioinformatics Analyst II -In addition to the education requirement, a minimum of two (2) years of progressively responsible experience
    • Bioinformatics Analyst III- In addition to the education requirement, a minimum of five (5) years of progressively responsible experience
  • Ability to obtain and maintain a security clearance

Candidates with these desired skills will be given preferential consideration:  

  • Possession of a Ph.D. degree in any quantitative science is preferred
  • Commitment to solving biological problems and communicating these solutions
  • Ability to multi-task across projects
  • Experience in submitting data sets to public repositories
  • Management of large genomic data sets including integration with data available from public sources
  • Prior customer-facing role
  • Record of scientific achievements including journal publications and conference presentations
  • Experience with multi-omic integration of NGS datasets
  • Familiarity with designing and deploying automated analysis pipelines on HPC and Cloud environments
  • Prior experience with analysis of single-cell and spatial transcriptomics datasets
Expected Competencies
  • Deep understanding of and experience in processing high throughput biomedical data: data cleaning, normalization, analysis, interpretation, and visualization
  • Ability to understand and analyze data from complex experimental designs
  • Proficiency in at least two of the following programming languages: Python, R, Perl, Java, and C/C++
  • Experience in at least two of the following areas: Exome sequencing, Bulk RNASeq, long-read technologies, DNA methylation analysis, single-cell transcriptomics, spatial transcriptomics
  • Familiarity with public databases: NCBI, Ensembl, TCGA, cBioPortal, Broad FireHose
  • Knowledge of working in a cluster environment

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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