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Scientist II, In Vivo Pharmacology

Employer
Maze Therapeutics
Location
South San Francisco, CA
Start date
Dec 1, 2023

View more

Discipline
Science/R&D, Biotechnology, Pharmacology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay

Job Details

The Position: 

Are you ready to make a meaningful impact in the world of pharmaceuticals?  At Maze Therapeutics, we’re on a mission to transform patient care through genetically informed therapies, focusing on common diseases like chronic kidney disease.  We’re looking for a Scientist to join our Pharmacology team where you’ll play a leading role in groundbreaking in vivo pharmacology studies and contribute to preclinical disease models and pharmacodynamic/target engagement assays, with special attention on the renal therapeutic area.  Your work will be crucial in supporting Maze’s drug discovery and development projects. 

Our dedication to novel mechanistic targets means that we often tackle challenging and exhilarating tasks.  Prior to identifying novel small molecule lead compounds, you may utilize techniques in transgenic mice or use ASO approaches to provide preclinical proof of concept, ensuring that a clinical solution is not just possible, but on the horizon.  While not mandatory, prior experience in preclinical (rodent) renal disease models, familiarity with disease biomarker analysis (e.g., by ELISA and Western blot), and basic histology skills will give you a head start.  You should thrive in the dynamic environment of a small biotech company and be ready to engage in multiple projects simultaneously. 

This role will report to the Associate Director of Pharmacology. 

Your Impact: 

  • Design and conduct in vivo studies and associated biomarker analyses to investigate target engagement or efficacy of small molecules (and potentially ASOs) in mouse and rat pharmacodynamic and disease models to support early lead identification and lead optimization 
  • Analyze pharmacodynamic/disease model data and present your findings to various audiences including the Pharmacology group, project teams, and company meetings within Maze
  • Represent the Pharmacology department on multi-disciplinary project core teams, ensuring seamless interaction with the Medicinal Chemistry, Biology, and DMPK groups.  This includes coordinating activities related to optimal timing of test material supply, sample bioanalysis, and assistance with PK/PD data analysis and interpretation
  • Guiding and encouraging the professional growth of junior team members
  • Adopt and lead routine histology activities to support in vivo disease model studies in the Pharmacology or Biology groups
  • Interact with external partners or CROs to manage studies and analyses as necessary 

Skills and Qualifications: 

  • Ph.D. (or equivalent experience) in pharmacology or related field and 2+ years of industry experience
  • Excellent communication skills and the ability to work in a team-based environment with passion and enthusiasm for pharmacology and drug discovery
  • Demonstrated track record for successfully establishing rodent in vivo pharmacodynamic and disease models to evaluate the activity of small molecule drug candidates
  • Proficient dosing via multiple routes (e.g., PO, IV, SC, and IP), biological sample collection, anesthetizing, and euthanizing rodents is essential.
  • Basic surgical skills (e.g., blood vessel catheterization) are advantageous
  • Ability to identify, highlight, and interpret relevant scientific literature to inform work and develop new protocols, and learn any new technologies and techniques that may be useful
  • Strong aptitude for maintaining flexibility to respond to changing project priorities
  • Demonstrated ability to provide scientific mentorship to junior colleagues within the team
  • Extremely detail-oriented and highly organized, taking pride in the consistent quality of your work

 

About Maze Therapeutics 

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases such as chronic kidney disease. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass PlatformTM, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass PlatformTM, Maze is building a broad portfolio of wholly owned and partnered programs. Maze is based in South San Francisco. 

  

Our People 

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.  

Our Core Values 

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.   

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.  

Stand True – Our integrity is foundational; it guides us no matter the obstacle.   

The expected annual salary range for employees located in the San Francisco Bay Area is $126,000 - $150,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.  

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. 

Company

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
 
What are genetic modifiers?
 
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
 
The Maze approach
 
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
 
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
Website
Location
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States

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