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Research Senior Scientist / Principal Scientist, Immunology, Oncology Cell Therapy Innovation

Boston, Massachusetts
Start date
Nov 30, 2023

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Job Details

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist / Principal Scientist, Oncology Cell Therapy Innovation in our Cambridge, MA office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.

The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy products to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platforms and novel engineering approaches to drive the discovery pipeline for Takeda Cell Therapy.


This position is seeking an experienced and highly motivated immunologist, who has a solid background in immunology, especially immuno-oncology and innate cell biology, to join the Cell Therapy Experimental Immunology team. We are looking for someone who is highly dedicated and driven to advance new therapies to patients and who has a strong work ethic, drive and collaborative mindset. The candidate will lead efforts in identifying new ways to optimize CAR-NK and CAR-γδT cell platforms byimproving our understanding of the basic biology of NK and γδT cells. The focus will be in discovering new ways to improve potency, persistence and immune modulation through developing a solid understanding of activation, survival, costimulation, differentiation, and suppressive mechanisms affecting these cells. The principal scientist will lead discovery projects and collaborate with colleagues within and across departments.

How you will contribute:
  • Contribute to pre-clinical/discovery work by designing, executing and leading experiments to further understand key pathways and mechanisms driving NK and γδ T cells biology

  • Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners.

  • Design, execute, and interpret functionalin vivo,in vitro, andex vivoassays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.

  • Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results.

  • Prepare and present comprehensive technical or project reports and formal presentations/posters to full range of internal/external audiences.

  • Ability to work independently and prioritize work in a fast-paced environment.

  • Maintain laboratory notebooks and follow laboratory practices in compliance.

  • Contribute to IND report and documentation.

  • Collaborate with cross-function teams and contribute in matrix-based project groups

  • Other job duties as assigned.

Minimum Requirements/Qualifications:
  • PhD degree in a scientific discipline with 6+ years experience, or MS with 12+ years experience, or BS with 14+ years experience

  • Minimum of 8+ years relevant pharmaceutical industry/academic experience post-graduation

  • Hands-on experience with CAR-T, CAR-NK, CAR-γδT, or TCR-T cell therapies/immunotherapies is required, including cell culture, immune cell activation/expansion, cytotoxicity assays, scRNAseq and high-throughput screening.

  • Profound skills in in vitro and in vivo immune cell characterization and functional assessment, such as, multi-color flow immunophenotyping, multiplex cytokine measurements, cytotoxicity assays, and other molecular based assays.

  • Experience with lentiviral transduction/CRISPR mediated KO/KI.

  • Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills.

  • Track record of publications to demonstrate scientific establishment.

What Takeda can offer you:
  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Ways of Working

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.


EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

For more information, visit

Stock Symbol: TAK

Company info
650 East Kendall Street
United States

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