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Principal Scientist / Associate Director -- Immunology, Genetic Engineering, Oncology Cell Therapy

Boston, Massachusetts
Start date
Nov 30, 2023

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Job Details

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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy product to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platform and novel engineering approaches to drive discovery pipeline for Takeda Cell Therapy

The Oncology Cell therapy Innovation team is seeking experienced molecular biologist who has a background in cancer immunology, genetic engineering especially non-viral mediated gene editing.

As a senior member of the team, you will play an important role in optimizing cell therapy platforms, e.g., CAR-NK, CAR-γδT, to improve the biological function (potency and persistence) of cell therapy products, based on solid understanding of innate cell biology, cancer/immune biology in tumor microenvironment and genetic engineering. You will lead discovery projects and collaborate with colleagues within department and cross-function teams to drive the development of Cell Therapy discovery platforms.

How you will contribute:
  • Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology cell therapy research.

  • Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners.

  • Design, execute, and interpret functionalin vivo,in vitro, andex vivoassays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.

  • Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through communication of study plans/value, and research results

  • Skill and breadth of knowledge in a scientific field

  • Stay current with scientific development (e.g. competitive landscape, new technology, new research portfolio, and new partnership)

  • Scientific leadership and establish rigorous standards for execution effectiveness

  • Have managerial responsibility

  • Independently control workload and demands

  • Scientifically independent

  • Scientific driver for research strategy that impacts group internally and outside area of function

  • Initiate and lead external interactions and collaborations

  • Frequent contact with internal and external personnel at multiple management levels

  • Elect approaches for new tasks and provide strategic project recommendations

Minimum Requirements/Qualifications:
  • Ph.D. in Immunology, Biology, Genetic Engineering, or related discipline.

  • Minimum of 6+ years relevant pharmaceutical industry/academic experience post-graduation

  • Hands on experience with CRISPR-, transposon-mediated genome engineering in multiple cell types.

  • Independently design sgRNAs, constructs for KO and KI through non-viral (plasmid, self-replicating vectors, EP, LNP) methods.

  • Profound skills in analytical methods such as flow cytometry, ddPCR, real-time PCR, off-targets evaluation, NGS etc.

  • Previous experience with CAR-T, CAR-NK, CAR-γδT, TCR-T cell immunotherapies, including cell culture, immune cell activation/expansion, viral transduction in vitro and in vivo immune cell characterization and function assessment, such as, multi-color flow immunophenotype, multiplex cytokine measurement, cytotoxicity assay is a plus

  • Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills.

  • Track record of publications to demonstrate scientific establishment.

What Takeda can offer you:
  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Ways of Working

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

For more information, visit

Stock Symbol: TAK

Company info
650 East Kendall Street
United States

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