In Vivo Pharmacology – Immuno-oncology (Senior Scientist I/II)
Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated biologist with a focus on immuno-oncology particularly T cell biology, who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics. The Senior Scientist I/II will design/perform tumor efficacy and PK/PD studies to understand how to effectively modulate the innate and adaptive immune system for new therapies. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology programs through the R&D pipeline.
Designs and executes/conducts in vivo studies (e.g. syngeneic, humanized mouse models, GEMMs, adoptive transfer systems) aimed at drug discovery in the immuno-oncology space
Uses detailed knowledge of state-of-the-art tools and approaches to enhance in vivo evaluation of novel therapeutics mechanism of action and/or identify new targets.
Participates in oncology target identification and validation.
Demonstrates a high level of initiative in troubleshooting experiments and performing data analysis.
Effectively collaborates across all intra and cross functional teams.
Presents research findings to project teams and governance bodies and prepares technical reports.
Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases.
Understands and adheres to IACUC protocols regarding animal welfare and handling.
Mentors and guides other scientists in the department; managerial experience preferred.
Commits to scientific rigor, high data quality and careful documentation.
Senior Scientist I/II: PhD in Immunology or a related discipline with 0+ (Sr Sci I) or 4+ (Sr Sci II) years of relevant research experience.
Hands-on expertise to design and perform complex in vivo experiments utilizing tumor models in both immunocompetent and immunocompromised mice; proficient in cell/drug administration via different routes (SC, IP, PO, IV).
Knowledgeable of secondary ex vivo cell-based assays across various technology platforms (e.g. FACS/cell sorting, imaging, ELISA/MSD, western blot/WES, IO-related culture systems, and omics-based approaches such as scRNA-seq) to assess target modulation levels and downstream effects at cellular, protein and gene level.
Extensive knowledge of immuno-oncology and tumor biology with proven publication record.
Demonstrated excellence and productivity in independent research.
Strong written and verbal communication skills.
Scientific leadership abilities and collaborative personality.
Detail-oriented, with excellent organizational and record-keeping skills.
PhD with 2+ years of experience in the pharmaceutical or biotechnology industry.
Hands-on experience and knowledge of humanized models, cell line-derived xenograft models, genetically engineered mouse models, adoptive immune cell transfer models, and/or in vivo genetic delivery platforms.
Extensive experience with T cell exhaustion, CAR-T, and in vivo targeted gene delivery.
Key Leadership Competencies:
Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment.
Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills.
Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment.
Raises the bar and is never satisfied with the status quo.
Excited to participate in and contribute to company culture.
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
Learns fast, grasps the "essence" and can change course quickly where indicated.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
· The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
· We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
· This job is eligible to participate in our short-term incentive programs.
· This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.